Gene: FGG
Official Full Name: fibrinogen gamma chainprovided by HGNC
Gene Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37890 | FGG Knockout cell line (A549) | Human | FGG | 1:3~1:4 | Negative | Online Inquiry |
FGG Gene Knockout Cell Lines are a specialized set of genetically engineered cell lines designed to facilitate the study of the FGG gene, a crucial component in the regulation of blood coagulation and the inflammatory response. These knockout cell lines are produced using state-of-the-art CRISPR/Cas9 technology, which allows for precise alterations in the genome by creating targeted deletions of the FGG gene. This gene disruption enables researchers to investigate the biological functions and pathways associated with fibrinogen gamma (FGG) in various physiological and pathological contexts.
The primary function of FGG Gene Knockout Cell Lines lies in their ability to provide a controlled environment for understanding the roles of the FGG gene in coagulation disorders, thrombotic diseases, and other relevant health conditions. By comparing these knockout lines to wild-type control cells, researchers can elucidate the gene's contribution to cellular mechanisms, such as platelet function and the regulation of inflammatory pathways, leading to advancements in therapeutic strategies.
In clinical and research settings, FGG Gene Knockout Cell Lines hold significant importance for drug discovery and the development of gene therapies. Their unique capacity to model specific genetic disorders provides an invaluable tool for understanding complex disease mechanisms. Researchers can utilize these cell lines to test potential pharmaceutical agents that target fibrinogen-related pathways or to investigate physiological responses in the absence of the FGG gene, further promoting the advancement of personalized medicine.
What sets FGG Gene Knockout Cell Lines apart from alternative products is their high fidelity and reliability, achieved through meticulous quality control and validation processes. The lines are fully characterized, ensuring consistent performance across various applications, including gene expression studies and cellular response assays. Additionally, our product offers streamlined protocols for transfection and manipulation, allowing researchers to focus on their science rather than troubleshooting experimental setups.
In an era where precision medicine is becoming essential, the FGG Gene Knockout Cell Lines afford researchers and clinicians the necessary tools to dissect disease mechanisms and foster the development of targeted therapies. Our company prides itself on its dedication to excellence in biological product innovation, ensuring that we deliver high-quality, cutting-edge tools that empower life sciences research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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