Gene: FGD4
Official Full Name: FYVE, RhoGEF and PH domain containing 4provided by HGNC
Gene Summary: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29235 | FGD4 Knockout cell line (HeLa) | Human | FGD4 | 1:3~1:6 | Negative | Online Inquiry |
KO29236 | FGD4 Knockout cell line (HCT 116) | Human | FGD4 | 1:2~1:4 | Negative | Online Inquiry |
KO29237 | FGD4 Knockout cell line (HEK293) | Human | FGD4 | 1:3~1:6 | Negative | Online Inquiry |
KO29238 | FGD4 Knockout cell line (A549) | Human | FGD4 | 1:3~1:4 | Negative | Online Inquiry |
FGD4 Gene Knockout Cell Lines represent a pioneering tool in molecular biology, specifically designed for the study of the FGD4 gene's role in various biological processes and disease mechanisms. These cell lines have been meticulously engineered using CRISPR-Cas9 technology to create stable knockout models that facilitate gene function analysis, allowing researchers to investigate the implications of FGD4 deficiency in different cellular contexts.
The primary function of these knockout cell lines is to provide a controlled environment for assessing the impact of the absence of FGD4 on cellular behaviors such as proliferation, differentiation, signaling pathways, and response to therapeutic agents. By systematically analyzing these cellular responses, researchers can uncover the molecular mechanisms downstream of FGD4, a protein implicated in cytoskeletal dynamics and potentially in conditions such as Charcot-Marie-Tooth disease.
The scientific importance of FGD4 Gene Knockout Cell Lines extends into both research and clinical settings, where they serve as critical models for exploring gene therapy approaches, drug discovery, and the underlying biology of genetic disorders. Their use can significantly accelerate the pathway from bench to bedside by elucidating targets for intervention in FGD4-associated pathologies.
Unique selling points of these knockout cell lines include their high specificity and efficiency achieved through state-of-the-art gene editing techniques, which sets them apart from traditional methods that may yield off-target effects. Additionally, the consistent and reproducible results generated from these models enhance their reliability for high-throughput screening applications.
For researchers and clinicians, investing in FGD4 Gene Knockout Cell Lines can substantially enrich their studies, opening pathways for novel therapeutic discoveries and improving our understanding of genetic influences in diseases. We are committed to advancing scientific research and clinical application through our extensive product offerings, ensuring that our clients have access to high-quality, readily usable biological models that meet stringent scientific standards.
Please note that all services are for research use only. Not intended for any clinical use.
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