Gene: FERMT3
Official Full Name: FERM domain containing kindlin 3provided by HGNC
Gene Summary: Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03907 | FERMT3 Knockout cell line (HCT 116) | Human | FERMT3 | 1:2~1:4 | Negative | Online Inquiry |
KO03908 | FERMT3 Knockout cell line (A549) | Human | FERMT3 | 1:3~1:4 | Negative | Online Inquiry |
FERMT3 Gene Knockout Cell Lines are genetically engineered cell lines in which the FERMT3 gene, encoding for fermitin family member 3, has been systematically disrupted or inactivated. This product serves as a crucial tool for researchers investigating the role of the FERMT3 protein in various biological processes, including cell adhesion, migration, and signal transduction. By using these knockout cell lines, scientists can observe the phenotypic changes that arise from the absence of FERMT3, thereby elucidating its specific functions and relevance in cell biology.
The primary mechanism of these knockout cell lines involves the targeted deletion of the FERMT3 gene through CRISPR-Cas9 technology, allowing researchers to study the resulting cellular behaviors in a controlled experimental setup. In particular, FERMT3 plays a significant role in cellular interactions and stability, and its absence can provide insights into conditions such as cancer metastasis, inflammatory responses, and tissue repair mechanisms. As such, these knockout cell lines are invaluable for both basic research and the development of therapeutic strategies.
The scientific importance of FERMT3 Gene Knockout Cell Lines extends to various research areas, including cancer biology, immunology, and regenerative medicine. They are especially beneficial in drug discovery and validation processes, as understanding the specific pathways influenced by FERMT3 can lead to novel intervention points for therapeutic targeting.
Compared to existing alternatives, these knockout cell lines offer enhanced specificity and reliability in experimental outcomes, enabling accurate assessments of gene function and cellular dynamics. Importantly, the use of our FERMT3 Gene Knockout Cell Lines minimizes off-target effects typically seen with conventional knockout methods, making them superior tools for rigorous scientific study.
Researchers and clinicians requiring precise models for gene function analysis will find significant value in these cell lines. They provide an opportunity to deepen understanding of FERMT3's biological roles while facilitating advancements in essential therapeutic fields. Our company's expertise in genetic engineering and cellular biology ensures that these cell lines are of the highest quality, providing robust platforms for innovative scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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