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FBXW9 Knockout Cell Lines

Gene: FBXW9

Official Full Name: F-box and WD repeat domain containing 9provided by HGNC

Gene Summary: Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25014 FBXW9 Knockout cell line (HeLa) Human FBXW9 1:3~1:6 Negative Online Inquiry
KO25015 FBXW9 Knockout cell line (HCT 116) Human FBXW9 1:2~1:4 Negative Online Inquiry
KO25016 FBXW9 Knockout cell line (HEK293) Human FBXW9 1:3~1:6 Negative Online Inquiry
KO25017 FBXW9 Knockout cell line (A549) Human FBXW9 1:3~1:4 Negative Online Inquiry

Background

FBXW9 Gene Knockout Cell Lines are specialized cell models that have been engineered to exhibit the complete absence of the FBXW9 gene. This gene plays a crucial role in various biological processes, including cell cycle regulation and protein degradation pathways. By utilizing CRISPR-Cas9 technology or other gene-editing techniques, these cell lines facilitate the investigation of FBXW9's functional roles in cellular mechanisms, thus providing researchers with a powerful tool to explore gene function and regulation.

The key mechanism of action for these knockout cell lines involves the introduction of targeted mutations that disrupt the transcription of the FBXW9 gene. This results in the organism's inability to express functional FBXW9 proteins, thereby illuminating the role of this gene in cellular responses and potential disease states. Researchers can observe how the absence of FBXW9 influences various pathways, such as those involved in cancer progression or metabolic disorders, enabling insights into therapeutic targets.

In scientific and clinical research contexts, FBXW9 Gene Knockout Cell Lines hold significant importance. They aid in elucidating the molecular underpinnings of diseases and contribute to the development of novel therapeutic strategies. Their application in high-throughput screening assays, drug discovery, and functional genomics makes them indispensable for investigators aiming to validate gene functions or to develop personalized medical approaches.

One of the unique advantages of our FBXW9 Gene Knockout Cell Lines is their robust reproducibility and ease of use, allowing for streamlined experimental protocols. Unlike other available cell models, which may not replicate the knockout phenomenon accurately, our product guarantees a consistent and reliable method for studying gene function over multiple experiments. This reliability translates into trustworthiness in experimental design, providing an edge in scientific inquiry.

For researchers and clinicians looking to deepen their understanding of the FBXW9 gene and its associated pathways, our knockout cell lines offer unmatched value. They enable the identification of specific molecular interactions and potentially pave the way for groundbreaking discoveries in gene therapy and biomarker identification.

Our company prides itself on a strong foundation of expertise in cellular biology and genetic engineering. We are dedicated to providing high-quality, validated biological products that support the advancement of research and therapeutic development in diverse fields. With our commitment to scientific excellence, we equip researchers and clinicians with the tools needed to drive innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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