Gene: FBXW2
Official Full Name: F-box and WD repeat domain containing 2provided by HGNC
Gene Summary: F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28230 | FBXW2 Knockout cell line (HeLa) | Human | FBXW2 | 1:3~1:6 | Negative | Online Inquiry |
KO28231 | FBXW2 Knockout cell line (HCT 116) | Human | FBXW2 | 1:2~1:4 | Negative | Online Inquiry |
KO28232 | FBXW2 Knockout cell line (HEK293) | Human | FBXW2 | 1:3~1:6 | Negative | Online Inquiry |
KO28233 | FBXW2 Knockout cell line (A549) | Human | FBXW2 | 1:3~1:4 | Negative | Online Inquiry |
FBXW2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the FBXW2 gene's function and regulation in a controlled environment. This innovative product involves the targeted deletion of the FBXW2 gene through state-of-the-art CRISPR/Cas9 technology, creating a versatile platform for researchers exploring gene function and its implications in various biological processes.
The primary function of these knockout cell lines is to provide insight into the role of FBXW2 in protein ubiquitination and degradation pathways, as well as its involvement in cellular responses to stress and proliferation. By assessing the biological consequences of FBXW2 ablation, researchers can dissect its contributions to disease mechanisms, particularly in cancer, where dysregulation of ubiquitin-proteasome system components is often implicated.
From a research and clinical standpoint, FBXW2 gene knockout models are invaluable tools for elucidating molecular pathways and validating therapeutic targets. Their application extends to drug discovery and testing, enabling the identification of compounds that specifically target FBXW2-related mechanisms. This precision contributes to more efficient and effective drug development processes critical for advancing personalized medicine.
What sets FBXW2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability. Conventional gene knockdown methods often lack the permanence required for long-term studies. In contrast, our knockout lines ensure that FBXW2 is consistently inactive, allowing for reproducibility in experiments and yielding robust data that enhance the validity of research findings.
For researchers and clinicians, the value of FBXW2 Gene Knockout Cell Lines lies in their ability to accelerate scientific discovery and facilitate advancements in tailored therapies. The unique insights provided by these models can lead to novel interventions that address critical health challenges.
Our company specializes in the development and provision of innovative biological products designed to advance research and improve clinical outcomes. With a commitment to quality and scientific excellence, we ensure that our offerings, such as FBXW2 Gene Knockout Cell Lines, empower researchers to unlock the complexities of biology.
Please note that all services are for research use only. Not intended for any clinical use.
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