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FBXO7 Knockout Cell Lines

Gene: FBXO7

Official Full Name: F-box protein 7provided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28824 FBXO7 Knockout cell line (HeLa) Human FBXO7 1:3~1:6 Negative Online Inquiry
KO28825 FBXO7 Knockout cell line (HCT 116) Human FBXO7 1:2~1:4 Negative Online Inquiry
KO28826 FBXO7 Knockout cell line (HEK293) Human FBXO7 1:3~1:6 Negative Online Inquiry
KO28827 FBXO7 Knockout cell line (A549) Human FBXO7 1:3~1:4 Negative Online Inquiry

Background

FBXO7 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the functional role of the FBXO7 gene, which encodes an F-box protein integral to various biological processes, including cell cycle regulation and protein degradation through the ubiquitin-proteasome pathway. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a targeted knockout of the FBXO7 gene, allowing researchers to investigate the consequences of its absence on cellular function and development.

The key mechanism of action involves the disruption of FBXO7’s role in mediating ubiquitination, a process crucial for controlling protein levels and maintaining cellular homeostasis. This knockout model enables scientists to explore the gene's involvement in diseases such as cancer and neurodegenerative disorders, where dysregulation of protein turnover may play a significant role. By providing a controlled environment to study FBXO7’s cellular functions, these knockout cell lines serve as a valuable tool in both basic research and drug discovery initiatives.

In comparison to traditional gene silencing techniques, such as RNA interference, the FBXO7 Gene Knockout Cell Lines offer greater specificity and permanence in genetic modification, leading to more reliable experimental outcomes. This fidelity enhances the validity of the research findings, enabling researchers to draw more robust conclusions regarding the gene's roles and implications in human health.

The unique capabilities of the FBXO7 Gene Knockout Cell Lines extend to applications in precision medicine and biomarker discovery, making them indispensable in the search for novel therapeutic targets. As we advance our understanding of the molecular mechanisms underlying various pathologies, these cell lines provide a vital resource for both academia and industry alike.

With a commitment to excellence in biological product development, our company leverages cutting-edge technology and extensive expertise, ensuring that our FBXO7 Gene Knockout Cell Lines meet the high standards necessary for impactful scientific research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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