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FBXO36 Knockout Cell Lines

Gene: FBXO36

Official Full Name: F-box protein 36provided by HGNC

Gene Summary: Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26589 FBXO36 Knockout cell line (HeLa) Human FBXO36 1:3~1:6 Negative Online Inquiry
KO26590 FBXO36 Knockout cell line (HCT 116) Human FBXO36 1:2~1:4 Negative Online Inquiry
KO26591 FBXO36 Knockout cell line (HEK293) Human FBXO36 1:3~1:6 Negative Online Inquiry
KO26592 FBXO36 Knockout cell line (A549) Human FBXO36 1:3~1:4 Negative Online Inquiry

Background

FBXO36 Gene Knockout Cell Lines are innovative biological tools engineered to facilitate the study of the FBXO36 gene, known for its role in ubiquitin-mediated proteolysis and cellular regulation. Knockout models provide researchers with a means to explore the gene's functional significance by eliminating its expression, enabling a deeper understanding of the biological pathways in which it operates.

These cell lines exhibit a precise alteration in the genome, achieved through advanced gene-editing techniques such as CRISPR-Cas9 or engineered homologous recombination. By disrupting the FBXO36 gene, these models allow scientists to observe changes in cellular processes, including cell cycle regulation, apoptosis, and signaling pathways. The elucidation of FBXO36's function can shed light on its potential implications in disease states, including cancer and neurodegenerative disorders, making these cell lines invaluable in both basic research and translational studies.

The scientific importance of FBXO36 Gene Knockout Cell Lines lies in their capacity to provide clear, replicable results that enhance our understanding of gene function. Compared to traditional overexpression or silencing approaches, these knockout lines offer a more definitive exploration of gene loss implications. The unparalleled specificity of FBXO36 knockout models paves the way for researchers to delineate the gene's roles without confounding factors.

Researchers and clinicians recognize the exceptional value of these cell lines in designing experiments that require robust models to assess gene function, drug discovery, and biomarker identification. Their availability streamlines experimental workflows and supports reproducible findings essential for advancing scientific knowledge.

With a longstanding commitment to excellence in the biotechnology field, our company prides itself on delivering high-quality, reliable gene knockout products. Our expertise in genetic engineering ensures that researchers have access to the most sophisticated tools necessary for advancing their scientific endeavors and ultimately contributing to the improvement of human health.

Please note that all services are for research use only. Not intended for any clinical use.

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