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FBXO28 Knockout Cell Lines

Gene: FBXO28

Official Full Name: F-box protein 28provided by HGNC

Gene Summary: Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01335 FBXO28 Knockout cell line (Huh-7) Human FBXO28 1:2~1:3 Negative Online Inquiry
KO29687 FBXO28 Knockout cell line (HeLa) Human FBXO28 1:3~1:6 Negative Online Inquiry
KO29688 FBXO28 Knockout cell line (HCT 116) Human FBXO28 1:2~1:4 Negative Online Inquiry
KO29689 FBXO28 Knockout cell line (HEK293) Human FBXO28 1:3~1:6 Negative Online Inquiry
KO29690 FBXO28 Knockout cell line (A549) Human FBXO28 1:3~1:4 Negative Online Inquiry

Background

FBXO28 Gene Knockout Cell Lines represent a groundbreaking tool for molecular biology studies, particularly in the field of gene function and regulation. These cell lines have been specifically engineered to have a targeted deletion of the FBXO28 gene, which encodes a component of the SKP1-CUL1-F-box (SCF) ubiquitin ligase complex. This manipulation allows researchers to delve deeply into the role of FBXO28 in various physiological processes, including proteasome-mediated protein degradation and cell cycle regulation.

The key function of FBXO28 lies in its involvement in the ubiquitination pathway, a crucial mechanism that governs protein turnover and cellular homeostasis. By knocking out this gene, scientists can better understand its contributions to protein stability and cellular signaling pathways, enabling the elucidation of FBXO28's role in oncogenesis and other diseases. The use of these knockout cell lines in experimental assays can significantly enhance the clarity and specificity of gene function studies.

The scientific importance of FBXO28 Gene Knockout Cell Lines extends to various applications in research and clinical settings. These versatile cell lines serve as invaluable models for drug testing, disease modeling, and the identification of novel therapeutic targets. By studying the phenotypic changes resulting from the loss of FBXO28, researchers can advance their understanding of cancer biology and explore potential interventions.

What sets FBXO28 Gene Knockout Cell Lines apart from alternative models is their precise and reliable genetic modification, ensuring consistent results across experiments. These cell lines are optimized for high efficiency, ease of use in a variety of assays, and compatibility with downstream applications such as CRISPR screening or RNA interference studies.

For researchers and clinicians alike, adopting FBXO28 Gene Knockout Cell Lines can significantly accelerate scientific discovery and foster innovative research capabilities. Their ability to clarify the understudied specifics of gene function offers a compelling pathway towards impactful findings.

Our company takes pride in its extensive expertise in the field of biological product development. We are committed to providing top-quality research tools like FBXO28 Gene Knockout Cell Lines, designed to empower researchers in their quest for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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