Gene: FBXO16
Official Full Name: F-box protein 16provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17661 | FBXO16 Knockout cell line (HCT 116) | Human | FBXO16 | 1:2~1:4 | Negative | Online Inquiry |
KO17662 | FBXO16 Knockout cell line (HEK293) | Human | FBXO16 | 1:3~1:6 | Negative | Online Inquiry |
KO17663 | FBXO16 Knockout cell line (A549) | Human | FBXO16 | 1:3~1:4 | Negative | Online Inquiry |
FBXO16 Gene Knockout Cell Lines are specialized cellular models generated to provide insights into the function and regulation of the FBXO16 gene, which encodes a member of the F-box protein family involved in ubiquitination processes. These cell lines have been meticulously engineered to ensure complete knockout of the FBXO16 gene, allowing researchers to study the resulting phenotypic alterations and regulatory pathways influenced by the absence of this critical component.
The primary mechanism by which FBXO16 influences cellular function relates to its role in protein degradation via the ubiquitin-proteasome pathway. This pathway is essential for regulating various cellular processes, including cell cycle progression, signal transduction, and apoptosis. By using FBXO16 knockout cell lines, researchers can investigate the downstream effects of this gene's ablation on cellular proliferation, differentiation, and response to stress, thus enhancing understanding of the biological processes tied to FBXO16.
The scientific importance of these cell lines cannot be overstated, as they serve as invaluable tools in both fundamental biological research and in the development of therapeutic strategies targeting diseases where protein homeostasis is disrupted, such as cancer and neurodegenerative disorders. In clinical settings, understanding FBXO16's role may reveal novel targets for drug development, making these cell lines a critical asset in translational research.
Compared to conventional cell lines, FBXO16 knockout models offer superior specificity in exploring gene function, providing clearer insights into the biological roles of this protein without the confounding effects of partial gene expression. Additionally, these cell lines are rigorously validated and characterized to ensure reproducibility and reliability, distinguishing them from alternative models that may lack such thorough characterization.
For researchers and clinicians concerned with the intricate dance of cellular regulation, FBXO16 Gene Knockout Cell Lines represent a critical contribution to the toolkit for modern biomedicine. Their development underscores our commitment to providing researchers with high-quality, innovative biological products designed to shed light on complex biological questions. At [Company Name], we specialize in advanced cellular models that empower scientific inquiry and drive discoveries that propel the life sciences forward.
Please note that all services are for research use only. Not intended for any clinical use.
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