Gene: FBXL20
Official Full Name: F-box and leucine rich repeat protein 20provided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24396 | FBXL20 Knockout cell line (HeLa) | Human | FBXL20 | 1:3~1:6 | Negative | Online Inquiry |
KO24397 | FBXL20 Knockout cell line (HCT 116) | Human | FBXL20 | 1:2~1:4 | Negative | Online Inquiry |
KO24398 | FBXL20 Knockout cell line (HEK293) | Human | FBXL20 | 1:3~1:6 | Negative | Online Inquiry |
KO24399 | FBXL20 Knockout cell line (A549) | Human | FBXL20 | 1:3~1:4 | Negative | Online Inquiry |
FBXL20 Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the FBXL20 gene, a crucial player in cellular regulatory mechanisms and protein degradation pathways. By utilizing the CRISPR-Cas9 gene-editing technology, these cell lines provide researchers with an invaluable tool to dissect the functional roles of the FBXL20 gene in various biological processes, including cell proliferation, differentiation, and response to stress.
The primary mechanism of these knockout cell lines involves the targeted disruption of the FBXL20 gene locus, resulting in the complete ablation of the gene's expression. This allows researchers to study phenotypic changes and molecular interactions directly related to the absence of FBXL20, which has implications for understanding disease mechanisms, particularly in cancer and developmental biology. Researchers can investigate downstream effects, revealing how the loss of FBXL20 impacts cellular behavior, signaling pathways, and interactions with other proteins.
The scientific importance of FBXL20 Gene Knockout Cell Lines lies in their broad applications in both research and clinical settings. For instance, they can facilitate the study of the gene's role in tumorigenesis, potentially leading to the identification of novel therapeutic targets. Additionally, these cell lines can be employed in drug screening assays to assess how the absence of FBXL20 influences responsiveness to various compounds, thereby informing personalized therapeutic strategies.
What sets our FBXL20 Gene Knockout Cell Lines apart from alternatives is their precise genetic modification, high reliability, and reproducibility in results, validated by extensive characterization. Unlike other models that may not accurately mimic the gene's absence, our cell lines provide a genuine representation of the biological effects of FBXL20 knockout, ensuring that experimental outcomes are both relevant and scientifically robust.
For researchers and clinicians looking to deepen their understanding of protein regulation and its implications in disease, FBXL20 Gene Knockout Cell Lines offer an unparalleled resource. With our commitment to high-quality biological products and a thorough understanding of genetic engineering, we ensure that our offerings advance the forefront of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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