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FBXL17 Knockout Cell Lines

Gene: FBXL17

Official Full Name: F-box and leucine rich repeat protein 17provided by HGNC

Gene Summary: Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17664 FBXL17 Knockout cell line (HeLa) Human FBXL17 1:3~1:6 Negative Online Inquiry
KO17665 FBXL17 Knockout cell line (HCT 116) Human FBXL17 1:2~1:4 Negative Online Inquiry
KO17666 FBXL17 Knockout cell line (HEK293) Human FBXL17 1:3~1:6 Negative Online Inquiry
KO17667 FBXL17 Knockout cell line (A549) Human FBXL17 1:3~1:4 Negative Online Inquiry

Background

FBXL17 Gene Knockout Cell Lines are engineered cellular models that facilitate the functional dissection of the FBXL17 gene, a member of the F-box protein family implicated in various cellular processes including protein degradation, cell cycle regulation, and stress response mechanisms. By employing CRISPR/Cas9 technology, these cell lines effectively eliminate the expression of FBXL17, providing a powerful tool for researchers aiming to investigate the gene's role in disease pathology, particularly in cancer and neurodegenerative disorders.

The primary function of these knockout cell lines is to enable scientists to study the phenotypic and molecular outcomes resulting from the absence of FBXL17. Researchers can assess changes in cell proliferation, apoptosis, and migration, as well as alterations in gene expression profiles through various experimental approaches including transcriptomics and proteomics. This functional analysis can yield insights into FBXL17’s regulatory networks and its potential contributions to disease mechanisms.

The scientific importance of FBXL17 Gene Knockout Cell Lines lies in their application in both fundamental research and drug discovery. They serve as models to test the efficacy of therapeutic agents targeting signaling pathways associated with FBXL17, thus playing a critical role in the development of novel cancer therapies and addressing other disorders linked to dysregulation of protein homeostasis.

Compared to conventional knockout methods, our FBXL17 Gene Knockout Cell Lines offer enhanced specificity and efficiency, minimizing off-target effects and providing a clearer understanding of gene function. Additionally, these cell lines are easily adaptable to various experimental setups, making them a versatile choice for researchers.

For researchers and clinicians, the value of these cell lines extends beyond their immediate experimental applications; they are instrumental in bridging the gap between basic science and translational research. By utilizing our genetically engineered models, users can accelerate their research endeavors and uncover novel biological insights.

Our company is committed to advancing biological research by providing high-quality, customizable models that empower scientists in their quest for knowledge. With extensive expertise in genetic engineering and molecular biology, we deliver products designed to meet the rigorous demands of today’s research landscape.

Please note that all services are for research use only. Not intended for any clinical use.

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