Gene: FBH1
Official Full Name: F-box DNA helicase 1provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24535 | FBH1 Knockout cell line (HeLa) | Human | FBH1 | 1:3~1:6 | Negative | Online Inquiry |
KO24536 | FBH1 Knockout cell line (HCT 116) | Human | FBH1 | 1:2~1:4 | Negative | Online Inquiry |
KO24537 | FBH1 Knockout cell line (HEK293) | Human | FBH1 | 1:3~1:6 | Negative | Online Inquiry |
KO24538 | FBH1 Knockout cell line (A549) | Human | FBH1 | 1:3~1:4 | Negative | Online Inquiry |
FBH1 Gene Knockout Cell Lines are specialized cellular models engineered to specifically delete or "knock out" the FBH1 gene, which encodes a key protein involved in various cellular processes including DNA damage response, repair, and apoptosis. By utilizing precise genome-editing technologies such as CRISPR/Cas9, these knockout cell lines facilitate in-depth functional studies of the FBH1 gene, enabling researchers to unravel its roles in both normal physiology and the pathogenesis of diseases, particularly cancer.
The primary function of FBH1 is to regulate the stability of specific DNA repair proteins, thereby influencing cellular responses to genomic stress. By investigating these knockout models, researchers can elucidate the mechanisms through which FBH1 contributes to genome integrity and tumorigenesis. This understanding is crucial not only for basic biological research but also for developing targeted cancer therapies and improving therapeutic strategies.
The scientific significance of FBH1 Gene Knockout Cell Lines extends into both foundational and applied research settings. These models serve as vital tools in drug discovery, biomarker identification, and the development of novel therapeutic approaches. With the ability to assess genetic compensation, functional redundancy, and cellular fate decisions, they offer unparalleled insights into the molecular underpinnings of cancer biology.
What sets our FBH1 Gene Knockout Cell Lines apart from alternatives is their rigorous validation, ensuring the precise deletion of the FBH1 gene without off-target effects. Additionally, our cell lines are marketed with comprehensive user protocols and extensive support for experimental design, providing a seamless integration experience into existing research workflows.
For researchers and clinicians engaged in cutting-edge studies, the FBH1 Gene Knockout Cell Lines represent a significant advancement in their toolkit, fostering greater innovation and discovery in genetic research and clinical applications. With years of experience in producing high-quality biological products, our company stands committed to supporting the scientific community with unparalleled resources and expertise in genetic engineering technologies.
Please note that all services are for research use only. Not intended for any clinical use.
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