Gene: FAR1
Official Full Name: fatty acyl-CoA reductase 1provided by HGNC
Gene Summary: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25117 | FAR1 Knockout cell line (HeLa) | Human | FAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO25118 | FAR1 Knockout cell line (HCT 116) | Human | FAR1 | 1:2~1:4 | Negative | Online Inquiry |
KO25119 | FAR1 Knockout cell line (HEK293) | Human | FAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO25120 | FAR1 Knockout cell line (A549) | Human | FAR1 | 1:3~1:4 | Negative | Online Inquiry |
FAR1 Gene Knockout Cell Lines are genetically modified human cell lines designed to study the functional implications of the FAR1 gene, known to play a crucial role in various biological processes, including cellular proliferation, differentiation, and apoptosis. By utilizing CRISPR/Cas9 technology, these cell lines exhibit a precise disruption of the FAR1 gene, allowing researchers to explore its role in cell signaling pathways and its impact on disease states, particularly in cancer research where FAR1 is implicated in tumorigenesis and metastasis.
The key mechanism of action involves the targeted deletion of the FAR1 gene, which results in the loss of its encoded protein. This knockout model can facilitate the investigation of compensatory pathways and gene interactions that may arise due to the absence of FAR1, thus providing insights into the adaptability of cellular mechanisms in response to genetic perturbation. Researchers can employ these cell lines in various assays, including proliferation, migration, and invasion studies, to assess the broader biological implications of FAR1 loss.
Scientifically, these cell lines are invaluable tools for elucidating the roles of FAR1 in pathophysiological contexts and can be instrumental in drug discovery and development, particularly for therapeutics targeting cancer. Compared to other gene knockout models, FAR1 Gene Knockout Cell Lines offer a high level of specificity and reproducibility, significantly enhancing the reliability of experimental results.
The unique selling point of our FAR1 Gene Knockout Cell Lines lies not only in their robust genetic modification but also in the proven track record of their performance in preclinical studies. Their availability for high-throughput screening makes them suitable for both foundational research and advanced clinical applications.
By choosing our FAR1 Gene Knockout Cell Lines, researchers and clinicians gain access to a meticulously curated product backed by our company's expertise in genetic engineering and commitment to advancing scientific discovery. Our team of dedicated professionals is continually engaged in enhancing these models, ensuring that users can fully exploit their potential in cancer research and beyond.
Please note that all services are for research use only. Not intended for any clinical use.
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