Gene: FAM111B
Official Full Name: FAM111 trypsin like peptidase Bprovided by HGNC
Gene Summary: This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17816 | FAM111B Knockout cell line (HeLa) | Human | FAM111B | 1:3~1:6 | Negative | Online Inquiry |
KO17817 | FAM111B Knockout cell line (HCT 116) | Human | FAM111B | 1:2~1:4 | Negative | Online Inquiry |
KO17818 | FAM111B Knockout cell line (HEK293) | Human | FAM111B | 1:3~1:6 | Negative | Online Inquiry |
KO17819 | FAM111B Knockout cell line (A549) | Human | FAM111B | 1:3~1:4 | Negative | Online Inquiry |
FAM111B Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically exclude the FAM111B gene, which encodes a protein known to play a crucial role in DNA damage response and maintenance of genomic integrity. By utilizing CRISPR-Cas9 gene editing technology, these cell lines provide an invaluable tool for researchers seeking to investigate the functional implications of FAM111B loss in cellular processes, genetic disorders, and cancer biology.
The key function of these cell lines lies in their ability to mimic the biological and pathological conditions present in FAM111B-deficient scenarios. This allows researchers to explore the gene's involvement in cellular proliferation, survival, and recombination processes, as well as its role in associated diseases. The generated knockout models are essential for elucidating the mechanisms underlying FAM111B-related pathologies, thereby promoting a better understanding of its contributions to genomic stability and cancer progression.
The scientific importance of FAM111B Gene Knockout Cell Lines extends to both fundamental research and clinical applications. Researchers can leverage these models in drug discovery, genetic screening, and mechanistic studies, potentially leading to novel therapeutic strategies aimed at targeting FAM111B-related pathways in various malignancies. Moreover, their utilization can facilitate the development of precision medicine approaches tailored to the genetic profiles of patients exhibiting abnormalities in DNA repair mechanisms.
Compared to alternative models, such as transient knockdown systems, FAM111B Gene Knockout Cell Lines provide a more stable and efficient platform for long-term studies and reproducibility. The knockout strategy ensures complete gene loss, enabling more definitive conclusions regarding gene function and cellular behavior.
In a rapidly evolving field, these cell lines are not only a valuable asset for academic and commercial laboratories but also for clinical researchers aiming to enhance our understanding of genetic disorders. Our company, specialized in providing high-quality biological models, stands committed to advancing research capabilities through innovative solutions like FAM111B Gene Knockout Cell Lines, helping scientists drive their projects towards meaningful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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