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FADD Knockout Cell Lines

Gene: FADD

Official Full Name: Fas associated via death domainprovided by HGNC

Gene Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08346 FADD Knockout cell line (HeLa) Human FADD 1:3~1:6 Negative Online Inquiry
KO08347 FADD Knockout cell line (HCT 116) Human FADD 1:2~1:4 Negative Online Inquiry
KO08348 FADD Knockout cell line (HEK293) Human FADD 1:3~1:6 Negative Online Inquiry
KO08349 FADD Knockout cell line (A549) Human FADD 1:3~1:4 Negative Online Inquiry

Background

FADD Gene Knockout Cell Lines are genetically engineered cell lines that have had the FADD gene (Fas-Associated protein with Death Domain) specifically disrupted to study the implications of FADD deficiency in cellular processes. This knockout specifically allows researchers to observe the behavior of cells in the absence of this critical signaling protein, which plays a pivotal role in the apoptotic pathway and immune responses.

The primary functions of FADD involve mediating apoptosis and inflammation through the formation of death-inducing signaling complexes (DISCs). When the FADD gene is knocked out, researchers can investigate alterations in survival, proliferation, and differentiation processes, providing insights into various cellular pathways and potential diseases, including cancer and autoimmune disorders. By utilizing these knockout cell lines, scientists facilitate the dissection of FADD-related signaling cascades, thereby elucidating its roles in health and disease mechanisms.

The scientific importance of FADD Gene Knockout Cell Lines is substantial, as they offer a model for exploring therapeutic strategies targeting apoptosis evasion by cancer cells. In clinical research, these models can contribute to the development of novel drugs that aim to restore normal apoptosis in tumors that exhibit aberrant FADD signaling.

One significant advantage of using FADD Gene Knockout Cell Lines over alternative models is their specificity and reproducibility in studies focused on the apoptotic signaling pathway. Unlike transient knockdown methods, which can yield variable results, the stable knockout provides consistent data across experiments, enhancing the reliability of research findings.

Researchers and clinicians looking to deepen their understanding of apoptosis and its implications in disease will find invaluable insights through the use of these cell lines. By integrating advanced genetic engineering techniques, FADD Gene Knockout Cell Lines serve as a robust tool for pioneering discoveries in biomedical research.

Our company specializes in providing high-quality, genetically modified cell lines that empower scientists to explore complex biological systems with precision and accuracy. The FADD Gene Knockout Cell Lines exemplify our commitment to facilitating research in pivotal areas of life sciences, enabling breakthroughs that propel the field forward.

Please note that all services are for research use only. Not intended for any clinical use.

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