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Epha2 Knockout Cell Lines

Gene: Epha2

Official Full Name: Eph receptor A2provided by MGI

Gene Summary: Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including lens fiber cell morphogenesis; mammary gland epithelium development; and osteoclast differentiation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01240 Epha2 Knockout cell line (MC38) Mouse Epha2 1:2-1:4 Negative Online Inquiry
KO01246 Epha2 Knockout cell line (EO771) Mouse Epha2 1:2-1:4 Negative Online Inquiry

Background

Epha2 Gene Knockout Cell Lines are genetically engineered cells in which the Eph receptor A2 (Epha2) gene has been inactivated or "knocked out" using advanced gene-editing techniques such as CRISPR/Cas9. Epha2 plays a crucial role in cell communication and signaling processes, involved in developmental processes, the regulation of cell adhesion, and the modulation of cellular environments. These knockout cell lines serve as pivotal tools for investigating the biological functions of Epha2, unraveling pathways linked to cancer progression, neurodevelopmental disorders, and tissue regeneration.

The mechanism of Epha2 knockout is predicated on the precise alteration of the gene sequence that encodes for the Epha2 protein. By creating a loss-of-function mutation, researchers can effectively study the effects of Epha2 absence on cell growth, differentiation, and interaction with other cell types. This capability not only facilitates a clearer understanding of Epha2's role in biological systems but also highlights potential therapeutic targets for diseases where Epha2 is implicated.

In the realm of scientific research and clinical applications, Epha2 Gene Knockout Cell Lines are invaluable for basic research, drug discovery, and therapeutic development. They offer insights into signaling pathways and provide a model for studying tumor biology and evaluating anti-cancer drugs that aim to inhibit Epha2-mediated signaling. The precise genetic modification ensures reproducibility and reliability in experimental outcomes, making them superior to traditional cell models that may have variable expression levels.

When compared to alternative models, Epha2 Gene Knockout Cell Lines are particularly advantageous due to their robustness in elucidating gene function without the confounding effects of the target gene's expression. This specificity provides a clearer interpretation of experimental results, fostering advancements in our understanding of complex biological interactions related to Epha2.

Investing in Epha2 Gene Knockout Cell Lines means equipping yourself with a powerful tool that not only enhances research quality but also accelerates discovery in essential areas of study for both researchers and clinical professionals. Our company specializes in providing high-quality genetic models that cater to the needs of scientists and innovators, striving to advance research and enhance therapeutic strategies in the field of biomedical sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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