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EYA3 Knockout Cell Lines

Gene: EYA3

Official Full Name: EYA transcriptional coactivator and phosphatase 3provided by HGNC

Gene Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37938 EYA3 Knockout cell line (HeLa) Human EYA3 1:3~1:6 Negative Online Inquiry
KO37939 EYA3 Knockout cell line (HCT 116) Human EYA3 1:2~1:4 Negative Online Inquiry
KO37940 EYA3 Knockout cell line (HEK293) Human EYA3 1:3~1:6 Negative Online Inquiry
KO37941 EYA3 Knockout cell line (A549) Human EYA3 1:3~1:4 Negative Online Inquiry

Background

EYA3 Gene Knockout Cell Lines are specialized, genetically modified cell lines in which the EYA3 gene has been purposefully disrupted to study its biological functions and implications in disease states. This innovative tool is indispensable for researchers investigating the role of the EYA3 gene, which is a critical regulator in cellular processes such as proliferation, differentiation, and apoptosis. By utilizing CRISPR/Cas9 technology, these knockout cell lines allow for precise alterations in gene expression, providing insights into the pathways influenced by EYA3.

The key functions of the EYA3 Gene Knockout Cell Lines lie in their ability to facilitate the dissection of EYA3's role in various pathologies, including cancer and developmental disorders. Researchers can examine how the loss of EYA3 function affects cellular behavior, signal transduction, and gene expression profiles. This capability is particularly valuable for elucidating the mechanistic pathways that underpin these conditions, guiding therapeutic development and personalized medicine approaches.

Scientific advancements in understanding EYA3 transformations have profound implications in both academic and clinical settings. The implication of EYA3 in various tumor types makes these cell lines applicable in pharmacological studies, where drug responses can be assessed, or genetic compensations investigated. Their use enables researchers to develop targeted interventions that could significantly enhance treatment options.

Compared to traditional cell lines, the EYA3 Gene Knockout Cell Lines offer distinct advantages. They provide a clear and direct model for studying the effects of gene loss, circumventing the complexities and confounding factors associated with alternate models. Furthermore, the specificity of the knockout ensures that any observed changes in phenotype are attributable directly to the EYA3 signaling cascade, allowing for clearer interpretation of results.

For researchers and clinicians alike, the EYA3 Gene Knockout Cell Lines present a uniquely powerful tool. By harnessing their capabilities, scientists can accelerate their journey toward groundbreaking discoveries and potential therapeutic innovations. Our company specializes in producing high-quality, state-of-the-art genetic tools that drive forward biological research, underpinned by a commitment to excellence, reliability, and support for our scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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