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EXTL2 Knockout Cell Lines

Gene: EXTL2

Official Full Name: exostosin like glycosyltransferase 2provided by HGNC

Gene Summary: Enables alpha-1,4-N-acetylgalactosaminyltransferase activity and glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in N-acetylglucosamine metabolic process and UDP-N-acetylgalactosamine metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37942 EXTL2 Knockout cell line (HeLa) Human EXTL2 1:3~1:6 Negative Online Inquiry
KO37943 EXTL2 Knockout cell line (HCT 116) Human EXTL2 1:2~1:4 Negative Online Inquiry
KO37944 EXTL2 Knockout cell line (HEK293) Human EXTL2 1:3~1:6 Negative Online Inquiry
KO37945 EXTL2 Knockout cell line (A549) Human EXTL2 1:3~1:4 Negative Online Inquiry

Background

EXTL2 Gene Knockout Cell Lines are advanced biological tools specifically designed for studying the functional roles of the EXTL2 gene, which is known to be involved in glycosaminoglycan biosynthesis and contributes significantly to cellular processes such as cell adhesion and signaling. These knockout cell lines are engineered using CRISPR/Cas9 technology to achieve precise and reliable gene editing, effectively disrupting the EXTL2 gene expression in mammalian cell systems.

The primary function of the EXTL2 Gene Knockout Cell Lines is to provide researchers with a cellular model that allows for detailed examination of the biological implications of EXTL2 gene loss. By eliminating the EXTL2 gene, scientists can scrutinize resultant phenotypic changes, including alterations in glycosaminoglycan production and its downstream effects on cellular behavior, such as proliferation, migration, and response to various stimuli. This mechanism permits an unparalleled exploration into the pathological conditions associated with EXTL2 dysregulation, particularly in the context of congenital disorders, cancer biology, and tissue engineering applications.

From a scientific standpoint, these cell lines represent a significant advancement for both research and clinical applications. They facilitate insights into the molecular mechanisms underlying glycosaminoglycan-mediated signaling pathways and provide a platform for testing novel therapeutic strategies targeting related maladies. Unlike traditional gene knockouts, these CRISPR-engineered cell lines boast higher specificity and efficiency, reducing off-target effects and allowing for more rigorous experimental designs.

Moreover, EXTL2 Gene Knockout Cell Lines enable high throughput screening for drug discovery, offering a reliable assay system for evaluating potential pharmacological agents aimed at pathways influenced by the EXTL2 gene. This specificity and potential for therapeutic relevance distinguish these cell lines and make them indispensable for biomedical researchers and clinicians focusing on molecular genetics and cellular biology.

Our company specializes in the development of cutting-edge genetic tools and maintains a commitment to quality and innovation. With a team of experienced professionals in gene editing technologies, we strive to support the scientific community by providing reliable and effective products that enhance research outcomes and contribute to the understanding of genetic pathways.

Please note that all services are for research use only. Not intended for any clinical use.

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