Gene: EXOC6
Official Full Name: exocyst complex component 6provided by HGNC
Gene Summary: The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21640 | EXOC6 Knockout cell line (HeLa) | Human | EXOC6 | 1:3~1:6 | Negative | Online Inquiry |
KO21641 | EXOC6 Knockout cell line (HCT 116) | Human | EXOC6 | 1:2~1:4 | Negative | Online Inquiry |
KO21642 | EXOC6 Knockout cell line (HEK293) | Human | EXOC6 | 1:3~1:6 | Negative | Online Inquiry |
KO21643 | EXOC6 Knockout cell line (A549) | Human | EXOC6 | 1:3~1:4 | Negative | Online Inquiry |
EXOC6 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the EXOC6 gene, which plays a critical role in the exocytic pathway and membrane trafficking processes. By utilizing CRISPR/Cas9 technology for efficient gene disruption, these cell lines enable researchers to investigate the biological functions of EXOC6 by analyzing cellular behaviors in the absence of this essential component.
The primary mechanism behind the functionality of EXOC6 knockout cell lines involves the targeted deletion of the EXOC6 gene, which encodes a protein integral to vesicle formation and transport. Through this genetic alteration, researchers can elucidate the pathways influenced by EXOC6, including its impact on cell adhesion, migration, and signaling cascades. The knockout cell lines serve as a vital tool in dissecting the molecular underpinnings of various diseases where exocytosis is dysregulated, including cancer and neurodegenerative disorders.
In terms of scientific importance, the EXOC6 Gene Knockout Cell Lines find applications across a spectrum of research disciplines. They are indispensable for drug discovery, understanding disease mechanisms, and developing therapeutic strategies. Their ability to mimic pathological conditions without the confounding variables present in whole organisms makes them invaluable in preclinical models.
Compared to alternative gene knockout methods, our EXOC6 Gene Knockout Cell Lines are characterized by high efficiency, reliability, and reproducibility, significantly reducing experimental variability. Unlike traditional knockout models, which often involve a lengthy breeding process, our cell lines provide immediate accessibility to researchers, allowing for faster and more efficient project development.
These cell lines are particularly advantageous for researchers and clinicians focused on cellular biology, therapeutic development, and genetic studies. Their targeted nature and established background make them ideal for addressing specific research inquiries, furthering our understanding of cellular functions and disease pathologies associated with exocytic dysfunction.
At [Your Company Name], we pride ourselves on our commitment to advancing life sciences through innovative biological products. With our expertise in genetic engineering and cell line development, we provide researchers with cutting-edge tools necessary to drive their discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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