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ESRRA Knockout Cell Lines

Gene: ESRRA

Official Full Name: estrogen related receptor alphaprovided by HGNC

Gene Summary: The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00464 ESRRA knockout cell line (HCT 116) Human ESRRA 1:2~1:4 Negative Online Inquiry
KO37967 ESRRA Knockout cell line (HeLa) Human ESRRA 1:3~1:6 Negative Online Inquiry
KO37968 ESRRA Knockout cell line (HEK293) Human ESRRA 1:3~1:6 Negative Online Inquiry
KO37969 ESRRA Knockout cell line (A549) Human ESRRA 1:3~1:4 Negative Online Inquiry

Background

ESRRA Gene Knockout Cell Lines are meticulously engineered cellular models designed to study the effects of the estrogen-related receptor alpha (ESRRA) on cellular functions and signaling pathways. These knockout lines are generated using CRISPR-Cas9 technology, ensuring efficient and specific disruption of the ESRRA gene within a relevant cellular context. The loss of ESRRA expression allows researchers to investigate the gene's role in various biological processes, including metabolism, cellular differentiation, and response to hormonal stimuli.

The primary mechanism of action for ESRRA involves its function as a transcriptional regulator, influencing the expression of numerous target genes involved in energy homeostasis and mitochondrial biogenesis. By utilizing these knockout cell lines, scientists can elucidate the gene's impact on metabolic pathways, hormone signaling, and related disease states, such as obesity and diabetes. This makes ESRRA knockout models invaluable for both basic research and the development of novel therapeutic strategies.

In terms of scientific significance, ESRRA Gene Knockout Cell Lines serve as powerful tools in elucidating the gene's broad physiological implications and its potential as a therapeutic target. The unique selling point of our ESRRA knockout models lies in their high specificity and fidelity, allowing for precise gene disruption without off-target effects commonly associated with traditional gene editing techniques. This specificity ensures more reliable data, significantly enhancing the reproducibility of experimental findings.

Researchers and clinicians will greatly benefit from these cell lines due to their ease of use and the depth of insight they provide into ESRRA-related biological pathways. By better understanding ESRRA's roles, users can innovate treatments that address metabolic disorders and other related conditions.

With years of expertise in genetic engineering and cellular models, our company stands at the forefront of biological research solutions, dedicated to providing cutting-edge tools that empower scientific discovery and advance clinical research.

Please note that all services are for research use only. Not intended for any clinical use.

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