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ERP44 Knockout Cell Lines

Gene: ERP44

Official Full Name: endoplasmic reticulum protein 44provided by HGNC

Gene Summary: This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29922 ERP44 Knockout cell line (HeLa) Human ERP44 1:3~1:6 Negative Online Inquiry
KO29923 ERP44 Knockout cell line (HCT 116) Human ERP44 1:2~1:4 Negative Online Inquiry
KO29924 ERP44 Knockout cell line (HEK293) Human ERP44 1:3~1:6 Negative Online Inquiry
KO29925 ERP44 Knockout cell line (A549) Human ERP44 1:3~1:4 Negative Online Inquiry

Background

ERP44 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the ERP44 gene, a critical player in the endoplasmic reticulum (ER) stress response and protein folding mechanisms. These knockout cell lines serve as powerful tools for understanding the biological roles of ERP44 in cellular pathways, enabling researchers to dissect its involvement in various physiological and pathological processes such as cancer metabolism, neurodegeneration, and immune responses.

The functionality of ERP44 Gene Knockout Cell Lines is rooted in their ability to simulate conditions devoid of the ERP44 gene, allowing for the assessment of its impact on cellular signaling pathways and protein behavior. This is achieved through a deletion mechanism facilitated by CRISPR-Cas9 technology, ensuring precise and efficient gene targeting. Researchers can utilize these cell lines to elucidate the contributions of ERP44 in cellular homeostasis, particularly under conditions of ER stress, thereby enhancing our understanding of diseases associated with protein misfolding and aggregation.

Scientifically, the ability to manipulate gene expression using these knockout cell lines is invaluable in both research and clinical settings. They enable a deeper exploration of targeted therapeutic strategies aimed at modulating ERP44-related pathways, potentially leading to the development of innovative treatments for degenerative diseases and cancers. Compared to traditional wild-type models, the ERP44 Gene Knockout Cell Lines eliminate confounding variables, providing clearer insights into gene function and interactions.

What sets the ERP44 Gene Knockout Cell Lines apart from alternative models is their specific targeting capability and the comprehensive validation of the knockout efficiency and specificity provided by rigorous characterization. Researchers, clinicians, and biotechnology companies will find these cell lines to be essential in advancing their studies in molecular biology and therapeutic development.

Our company specializes in providing high-quality, precision-engineered cellular tools, ensuring that each product is backed by the latest advances in genetic manipulation technology. By choosing our ERP44 Gene Knockout Cell Lines, users gain access to an expertly developed resource that supports groundbreaking research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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