Gene: EPX
Official Full Name: eosinophil peroxidaseprovided by HGNC
Gene Summary: This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34269 | EPX Knockout cell line (HEK293) | Human | EPX | 1:3~1:6 | Negative | Online Inquiry |
EPX Gene Knockout Cell Lines are a specialized set of genetically modified cell lines designed to facilitate the study of gene function through the complete disruption of targeted gene expression via CRISPR-Cas9 technology. These cell lines are invaluable tools for researchers aiming to elucidate the role of specific genes in various biological processes, disease mechanisms, and therapeutic strategies. By knocking out the EPX gene, researchers can observe phenotypic changes, cellular responses, and molecular pathways that are directly influenced by the absence of this gene, enabling a deeper understanding of its biological significance.
The key functional mechanism behind EPX Gene Knockout Cell Lines involves precise genomic editing, wherein the CRISPR-Cas9 system introduces double-strand breaks at the target gene locus. The cellular repair processes then lead to insertions or deletions (indels) that disrupt the reading frame of the EPX gene, effectively silencing its expression. This molecular manipulation allows for the exploration of downstream effects on cellular behavior, interactions, and potential compensatory mechanisms.
The scientific importance of EPX Gene Knockout Cell Lines extends to various research fields, including cancer biology, metabolic disorders, and immunology. They serve as critical models in drug discovery, enabling high-throughput screening for potential therapeutics, and in the validation of gene targets for novel treatments. In clinical settings, the insights gained from using these cell lines can be pivotal for developing gene therapy approaches.
Compared to alternative methodologies such as RNA interference (RNAi) or traditional knockdown techniques, EPX Gene Knockout Cell Lines offer permanent gene disruption and can be utilized for long-term studies without the concerns of transient expression fluctuations. Their stability and reliability in experimental outcomes position them as superior choices for in-depth genetic research.
For researchers and clinicians alike, EPX Gene Knockout Cell Lines represent an essential asset that supports innovative investigations into gene function and potential therapeutic avenues. With a commitment to advancing genetic research, our company provides expertly developed biological products that empower the scientific community to uncover critical insights in molecular biology and genetics.
Please note that all services are for research use only. Not intended for any clinical use.
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