Gene: EPO
Official Full Name: erythropoietinprovided by HGNC
Gene Summary: This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00387 | EPO gRNA1-gRNA2 KO plasmid | EPO | $850 | |||
KO00709 | EPO Knockout cell line(HTR-8/SVneo) | Human | EPO | 1:2~1:4 | Negative | Online Inquiry |
EPO Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the erythropoietin (EPO) gene, which plays a critical role in the regulation of red blood cell production. These cell lines serve as invaluable tools for studying the function of EPO beyond its well-established role in hematopoiesis, allowing researchers to explore its involvement in various biological processes, including angiogenesis, cellular metabolism, and neuroprotection.
The key function of EPO Gene Knockout Cell Lines is to provide a controlled environment in which researchers can investigate the cellular mechanisms and pathways that are modulated by EPO signaling. By eliminating the EPO gene, these cell lines facilitate the assessment of downstream molecular effects and the development of EPO-targeted therapies. Additionally, they can aid in the investigation of EPO's potential roles in pathologies, such as cancer and cardiovascular diseases, where aberrant EPO signaling may contribute to disease progression.
The scientific importance of EPO Gene Knockout Cell Lines lies in their diverse applications in both research and clinical settings. They can be instrumental in drug development, allowing for the identification of potential EPO inhibitors or agonists and providing insights into therapeutic interventions for diseases characterized by dysfunctional EPO activity. Furthermore, these cell lines contribute to advancements in personalized medicine by offering platforms for studying patient-specific variations in EPO-related pathways.
In comparison to traditional cell line models, EPO Gene Knockout Cell Lines offer unique advantages: precise genetic modification, consistent reproducibility, and a clear understanding of the biological role of EPO. They eliminate confounding variables that arise in non-knockout systems, making them essential for high-confidence experimental outcomes.
For researchers and clinicians dedicated to unearthing the complexities of EPO signaling and its implications in health and disease, EPO Gene Knockout Cell Lines represent a significant resource. Their versatility and reliability make them indispensable in the continuing quest for innovative therapeutic strategies. Our company, with its commitment to cutting-edge genetic engineering and a robust portfolio of advanced biological products, is proud to support the scientific community with high-quality EPO Gene Knockout Cell Lines that empower research and fuel discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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