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EPC1 Knockout Cell Lines

Gene: EPC1

Official Full Name: enhancer of polycomb homolog 1provided by HGNC

Gene Summary: This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26011 EPC1 Knockout cell line (HeLa) Human EPC1 1:3~1:6 Negative Online Inquiry
KO26012 EPC1 Knockout cell line (HCT 116) Human EPC1 1:2~1:4 Negative Online Inquiry
KO26013 EPC1 Knockout cell line (HEK293) Human EPC1 1:3~1:6 Negative Online Inquiry
KO26014 EPC1 Knockout cell line (A549) Human EPC1 1:3~1:4 Negative Online Inquiry

Background

EPC1 Gene Knockout Cell Lines are specifically engineered cell lines in which the EPC1 gene has been selectively disrupted, allowing for the study of its biological functions and the consequences of its absence. EPC1, or "Enhancer of Polycomb 1", is involved in chromatin remodeling and gene regulation, and the knockout of this gene provides researchers with a powerful tool to dissect its role in various cellular processes, including differentiation, apoptosis, and genome stability.

The primary mechanism of action for the EPC1 Gene Knockout Cell Lines revolves around the elimination of EPC1-mediated interactions with chromatin, leading to altered transcriptional profiles. By studying these knockout cells, researchers can gain insights into the pathways influenced by EPC1, particularly those linked to cancer biology and developmental disorders. In cell culture and experimental setups, these knockout lines facilitate investigations into signaling pathways, gene expression changes, and cellular responses to environmental stimuli.

In terms of scientific importance, the EPC1 Gene Knockout Cell Lines provide a crucial model for understanding the epigenetic mechanisms governing gene expression, making them invaluable for both basic research and translational studies. Clinically, such models can potentially unveil novel therapeutic targets for diseases where EPC1's function is altered, offering implications for drug development and precision medicine.

The advantages of using EPC1 Gene Knockout Cell Lines over alternative models include their targeted gene disruption, which offers specificity and eliminates off-target effects frequently seen with other knockout approaches (e.g., CRISPR-Cas9 artifacts). Additionally, these cell lines are often validated with rigorous quality control measures, ensuring reproducibility and reliability in experimental setups.

For researchers and clinicians alike, the EPC1 Gene Knockout Cell Lines represent a significant resource for furthering our understanding of gene regulation and its implications in health and disease. By incorporating these specialized cell lines into their studies, users can advance their research with confidence in their findings.

At [Your Company Name], we pride ourselves on providing high-quality biological tools and models that empower scientific discovery. Our expertise in cell line development ensures that each product, including the EPC1 Gene Knockout Cell Lines, undergoes stringent testing to meet the highest standards of excellence, enabling researchers to push the boundaries of knowledge in molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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