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ENPEP Knockout Cell Lines

Gene: ENPEP

Official Full Name: glutamyl aminopeptidaseprovided by HGNC

Gene Summary: The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38035 ENPEP Knockout cell line (HCT 116) Human ENPEP 1:2~1:4 Negative Online Inquiry
KO38036 ENPEP Knockout cell line (HEK293) Human ENPEP 1:3~1:6 Negative Online Inquiry

Background

ENPEP Gene Knockout Cell Lines are genetically engineered cell lines designed to exhibit targeted deletions of the ENPEP gene, which encodes the enzyme aminopeptidase. This enzyme plays a critical role in various biological pathways, including the metabolism of peptides, which are essential for numerous physiological processes. By precisely knocking out the ENPEP gene, these cell lines facilitate the study of enzyme function, protein interactions, and the broader implications of aminopeptidase deficiency in cellular activities.

The key function of ENPEP Gene Knockout Cell Lines lies in their ability to serve as a model for investigating the physiological and pathological roles of aminopeptidases. Researchers can utilize these cell lines to explore mechanisms of peptide metabolism, understand signaling pathways, and evaluate potential therapeutic targets. The knockout approach allows scientists to delve into gene function and assess the resultant phenotypic changes compared to wild-type cells, thus providing insights into disease mechanisms and treatment efficacy.

The scientific importance of ENPEP Gene Knockout Cell Lines is underscored by their applications in both research and clinical settings, including drug development, toxicology testing, and understanding metabolic disorders. These cell lines are invaluable tools for researchers studying the implications of aminopeptidase activity in diseases such as hypertension, obesity, and certain cancers, enabling targeted investigations into new therapeutics.

Unlike traditional cell lines, ENPEP Gene Knockout Cell Lines offer specific and reproducible modifications that drastically reduce the variability often seen in experiments, thereby delivering more reliable data. Furthermore, these cell lines present enhanced specificity in research applications, making them superior to generalized knockdown models. They empower researchers to achieve a deeper understanding of gene function with a focus on enzyme-specific pathways, ensuring that experimental outcomes are both robust and translatable to clinical implications.

Our company prides itself on being at the forefront of genetic engineering technologies, providing high-quality biological products that advance scientific research. With a dedicated team of experts and a commitment to innovation, we ensure that our ENPEP Gene Knockout Cell Lines meet the rigorous demands of modern biological research, equipping researchers and clinicians with the essential tools needed to propel their studies forward.

Please note that all services are for research use only. Not intended for any clinical use.

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