Gene: EML1
Official Full Name: EMAP like 1provided by HGNC
Gene Summary: Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38052 | EML1 Knockout cell line (HeLa) | Human | EML1 | 1:3~1:6 | Negative | Online Inquiry |
KO38053 | EML1 Knockout cell line (HCT 116) | Human | EML1 | 1:2~1:4 | Negative | Online Inquiry |
KO38054 | EML1 Knockout cell line (HEK293) | Human | EML1 | 1:3~1:6 | Negative | Online Inquiry |
KO38055 | EML1 Knockout cell line (A549) | Human | EML1 | 1:3~1:4 | Negative | Online Inquiry |
EML1 Gene Knockout Cell Lines are engineered cell lines specifically designed to have a targeted deletion of the EML1 gene, a critical component involved in various cellular processes including microtubule dynamics and cellular signaling pathways. This product utilizes advanced CRISPR/Cas9 genome-editing technology to precisely disrupt the EML1 gene, ensuring a robust and reproducible model for research into its biological roles and implications in disease.
The primary function of EML1 Gene Knockout Cell Lines is to enable researchers to study the physiological and pathological processes altered by the absence of the EML1 gene. By examining these knockout models, scientists can elucidate the gene's function in cellular homeostasis, division, and its involvement in developmental biology. The knockout lines facilitate in-depth investigation into the mechanistic underpinnings of cancers and neurological disorders associated with EML1 dysregulation, making them invaluable for translational research.
Scientifically, these cell lines provide unprecedented opportunities for drug discovery and therapeutic interventions, especially in the context of targeted therapies. Researchers can use EML1 knockout models to test the efficacy and safety of novel compounds, streamlining the path from bench to bedside. Compared to traditional knockdown methods, EML1 Gene Knockout Cell Lines offer a definitive loss-of-function approach, eliminating variability and off-target effects, thus granting heightened accuracy in experimental outcomes.
For clinicians and researchers alike, these cell lines are crucial tools for advancing our understanding of complex biological systems. Their reliable performance enhances reproducibility in experimental setups, and their ease of use accelerates the research timeline, allowing for quicker insights and findings.
At [Your Company Name], we pride ourselves on our commitment to innovation and scientific excellence, providing cutting-edge biological products that empower our clients in their research endeavors. Our expertise in developing high-quality knockout models reflects our dedication to supporting the scientific community and advancing biomedicine.
Please note that all services are for research use only. Not intended for any clinical use.
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