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EMG1 Knockout Cell Lines

Gene: EMG1

Official Full Name: EMG1 N1-specific pseudouridine methyltransferaseprovided by HGNC

Gene Summary: This gene encodes an essential, conserved eukaryotic protein that methylates pseudouridine in 18S rRNA. The related protein in yeast is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00503 EMG1 gRNA3-gRNA4 KO plasmid EMG1 $850
KO01555 EMG1 Knockout cell line (HeLa) Human EMG1 1:3~1:6 Negative Online Inquiry
KO01556 EMG1 Knockout cell line (HCT 116) Human EMG1 1:2~1:4 Negative Online Inquiry
KO01557 EMG1 Knockout cell line (HEK293) Human EMG1 1:3~1:6 Negative Online Inquiry
KO01558 EMG1 Knockout cell line (A549) Human EMG1 1:3~1:4 Negative Online Inquiry

Background

EMG1 Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted gene editing to inactivate the EMG1 gene, which plays a crucial role in the biogenesis of ribosomal RNA. The targeted disruption of this gene allows for the study of its function and the broader implications of ribosome assembly and protein synthesis in various biological contexts. By utilizing cutting-edge CRISPR/Cas9 technology, these knockout cell lines facilitate an in-depth exploration of cellular mechanisms associated with ribosomal functions and their link to various diseases.

These cell lines are invaluable tools for researchers in elucidating the pathophysiology of disorders where ribosomal dysfunction is implicated, such as cancers and certain genetic syndromes. By studying EMG1 knockout models, researchers can dissect alternative pathways and compensatory mechanisms activated in the absence of this gene, thereby fostering hypothesis-driven research that is foundational for therapeutic development.

One of the standout features of the EMG1 Gene Knockout Cell Lines is their specificity and reproducibility, which ensure that results are both reliable and translatable to clinical settings. The robustness of these models surpasses traditional knockdown approaches, which may not completely silence the gene of interest or could produce off-target effects. Moreover, the unique ability to utilize these cell lines in various assays, such as drug response testing and metabolic profiling, amplifies their utility in both basic and applied research.

For researchers and clinicians aiming to unravel the complexities of ribosomal biology and its clinical implications, EMG1 Gene Knockout Cell Lines provide a robust platform for discovery. The integration of such advanced biological products into research frameworks not only accelerates scientific progress but also enhances the potential for developing targeted therapeutic interventions. As a leader in the field of biogenetics, our company remains committed to delivering high-quality research tools that empower scientific discovery and transformative advances in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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