Gene: ELOA
Official Full Name: elongin Aprovided by HGNC
Gene Summary: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35091 | ELOA Knockout cell line (HeLa) | Human | ELOA | 1:3~1:6 | Negative | Online Inquiry |
KO35092 | ELOA Knockout cell line (HCT 116) | Human | ELOA | 1:2~1:4 | Negative | Online Inquiry |
KO35093 | ELOA Knockout cell line (HEK293) | Human | ELOA | 1:3~1:6 | Negative | Online Inquiry |
KO35094 | ELOA Knockout cell line (A549) | Human | ELOA | 1:3~1:4 | Negative | Online Inquiry |
ELOA Gene Knockout Cell Lines are specially developed cellular models engineered to facilitate the study of gene function by selectively inactivating specific target genes. This innovative technology leverages CRISPR-Cas9 gene-editing tools to induce precise gene disruptions in various cell types, allowing researchers to systematically evaluate the effects of gene loss on cellular processes and signaling pathways. By creating knockout cell lines for genes of interest, users can gain invaluable insights into gene function, disease mechanisms, and potential therapeutic targets.
The primary mechanism of ELOA Gene Knockout Cell Lines centers around the CRISPR-Cas9 system, which employs guide RNA (gRNA) to direct the Cas9 nuclease to the targeted genomic location, generating double-strand breaks that trigger cellular repair pathways. This leads to insertions or deletions (indels) that effectively knock out the target gene, enabling researchers to investigate the phenotypic consequences of gene disruption in a controlled environment.
The significance of these knockout cell lines in both basic research and clinical applications cannot be overstated. They are instrumental in elucidating the roles of specific genes in diseases such as cancer, neurodegeneration, and genetic disorders. Moreover, they serve as powerful tools for drug discovery, allowing scientists to assess the efficacy of novel compounds against cells with particular genetic profiles.
One of the standout advantages of ELOA Gene Knockout Cell Lines is their robust validation and reliability compared to alternative models. Our cell lines are extensively characterized, ensuring consistent performance and reproducibility in experiments. Additionally, they come with comprehensive user support and detailed documentation to facilitate seamless integration into existing research workflows.
For researchers and clinicians seeking to make breakthroughs in gene function studies, ELOA Gene Knockout Cell Lines represent a critical resource. Their precision, reliability, and applicability across diverse scientific inquiries underline their value in advancing genomic research.
With decades of expertise in biological product development, our company is dedicated to providing innovative solutions that empower researchers and contribute to significant advancements in life sciences. ELOA Gene Knockout Cell Lines are a testament to our commitment to excellence and innovation in the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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