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ELK1 Knockout Cell Lines

Gene: ELK1

Official Full Name: ETS transcription factor ELK1provided by HGNC

Gene Summary: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10824 ELK1 Knockout cell line (HeLa) Human ELK1 1:3~1:6 Negative Online Inquiry
KO10825 ELK1 Knockout cell line (HCT 116) Human ELK1 1:2~1:4 Negative Online Inquiry
KO10826 ELK1 Knockout cell line (HEK293) Human ELK1 1:3~1:6 Negative Online Inquiry
KO10827 ELK1 Knockout cell line (A549) Human ELK1 1:3~1:4 Negative Online Inquiry

Background

ELK1 Gene Knockout Cell Lines are genetically engineered cell lines in which the ELK1 gene has been inactivated, providing a powerful tool for studying the functional role of this transcription factor in various biological processes. ELK1 is involved in significant cellular activities, including cell differentiation, proliferation, and responses to extracellular signals. By knocking out the ELK1 gene, researchers can observe the resultant phenotypic changes and better understand the pathway dynamics related to cell growth and signaling.

These cell lines function primarily by serving as a model to delineate ERK signaling pathways and their downstream impacts on gene expression. The knockout of ELK1 disrupts its usual function in regulating immediate early gene expression, allowing scientists to assess the consequences on cell behavior and function in vitro. This capability is invaluable for elucidating the mechanisms underlying various diseases, including cancer, where aberrant signaling pathways play a critical role.

In research and clinical settings, the ELK1 Gene Knockout Cell Lines are essential for studies aimed at identifying potential therapeutic targets, developing new drug screening systems, and elucidating the molecular basis of signaling cascades. Compared to alternatives, these cell lines provide a more precise tool for investigating the specific contributions of ELK1 to cellular processes, enhancing the reliability and validity of experimental results.

The unique selling points of these cell lines include their ease of use in standard laboratory protocols and the ability to generate reproducible data across experiments. They offer researchers and clinicians enhanced insights into the regulatory networks underpinning disease processes, thus streamlining the journey from basic research to clinical applications.

With a strong background in genetic engineering and cellular biology, our company is dedicated to providing high-quality biological products that empower scientific discovery. Our ELK1 Gene Knockout Cell Lines exemplify our commitment to supporting researchers in their quest for innovative solutions in the field of functional genomics.

Please note that all services are for research use only. Not intended for any clinical use.

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