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EFNA1 Knockout Cell Lines

Gene: EFNA1

Official Full Name: ephrin A1provided by HGNC

Gene Summary: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10833 EFNA1 Knockout cell line (HeLa) Human EFNA1 1:3~1:6 Negative Online Inquiry
KO10834 EFNA1 Knockout cell line (HCT 116) Human EFNA1 1:2~1:4 Negative Online Inquiry
KO10835 EFNA1 Knockout cell line (HEK293) Human EFNA1 1:3~1:6 Negative Online Inquiry
KO10836 EFNA1 Knockout cell line (A549) Human EFNA1 1:3~1:4 Negative Online Inquiry

Background

EFNA1 Gene Knockout Cell Lines are specially engineered cellular models designed to eliminate the expression of the EFNA1 gene, a key component involved in various biological pathways, including cell adhesion, migration, and interaction with the immune system. These knockout cell lines serve as vital tools for understanding the functional implications of EFNA1 in cellular processes and disease models.

The primary mechanism of action involves the targeted modification of the EFNA1 gene using advanced CRISPR/Cas9 technology or RNA interference methods. By disrupting the gene's coding sequence, these cell lines provide researchers with the ability to study the resulting phenotypic changes in cellular behavior, signaling cascades, and their implications in pathological contexts such as cancer, inflammation, and neurodegenerative diseases.

The scientific significance of EFNA1 Gene Knockout Cell Lines is multifaceted. They support fundamental research and drug discovery efforts by elucidating the roles of EFNA1 in various physiological and pathological conditions. Additionally, these cell lines can be employed in high-throughput screening assays, facilitating the identification of therapeutic compounds that modulate EFNA1-related pathways, thus bridging laboratory findings with clinical applications.

What sets EFNA1 Gene Knockout Cell Lines apart from other cellular models is their precision and reliability. Conventional approaches to gene silencing often yield heterogeneous results, while our knockout lines provide a stable, reproducible platform for experimental consistency. Moreover, the high efficiency of the knockout process ensures that researchers can confidently attribute observed effects specifically to the loss of EFNA1 function.

For researchers and clinicians focused on unraveling the complexities of disease mechanisms or developing new therapeutic strategies, the value of EFNA1 Gene Knockout Cell Lines is undeniable. They represent a crucial asset in the toolkit for modern molecular biology and translational medicine, enabling innovative discoveries that can lead to better patient outcomes.

Our company is dedicated to advancing scientific research by providing high-quality biological products, and our expertise in genetic and cellular technologies ensures that our EFNA1 Gene Knockout Cell Lines meet the rigorous standards demanded by today's researchers. We are committed to supporting your research endeavors with reliable and cutting-edge tools.

Please note that all services are for research use only. Not intended for any clinical use.

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