Gene: EED
Official Full Name: embryonic ectoderm developmentprovided by HGNC
Gene Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33916 | EED Knockout cell line (HeLa) | Human | EED | 1:3~1:6 | Negative | Online Inquiry |
KO33917 | EED Knockout cell line (HCT 116) | Human | EED | 1:2~1:4 | Negative | Online Inquiry |
KO33918 | EED Knockout cell line (HEK293) | Human | EED | 1:3~1:6 | Negative | Online Inquiry |
KO33919 | EED Knockout cell line (A549) | Human | EED | 1:3~1:4 | Negative | Online Inquiry |
EED Gene Knockout Cell Lines are specially engineered cell lines that have undergone precise genetic modification to knock out the Enhancer of Zeste Homolog 2 (EED) gene, a key component of the Polycomb Repressive Complex 2 (PRC2). This knockout effectively disrupts a significant epigenetic regulatory pathway, providing a powerful tool for studying gene expression and regulation mechanisms in cellular contexts. By utilizing CRISPR/Cas9 or other gene-editing technologies, researchers can generate these knockout lines with high specificity, enabling them to investigate the phenotypic consequences of EED loss in various biological processes.
The primary function of EED involves mediating transcriptional repression through chromatin remodeling, thereby influencing cellular differentiation, proliferation, and development. By employing EED Gene Knockout Cell Lines, researchers can elucidate the roles of EED in oncogenesis, stem cell biology, and developmental pathways, paving the way for innovative therapeutic strategies targeting epigenetic modifications in diseases such as cancer.
The scientific significance of these cell lines lies in their applicability in both basic and translational research. They serve as invaluable models in drug discovery assays, epigenetic modulation studies, and toxicology testing, offering insights into how EED influences gene networks. Unlike traditional wild-type cell lines, EED knockout lines provide a more accurate representation of the cellular behavior in the absence of specific epigenetic factors.
One of the standout advantages of the EED Gene Knockout Cell Lines is their unparalleled specificity and functional validation, which allows for precise experimental designs and reproducibility. This is essential for generating robust data that can accelerate research timelines and enhance the quality of outcomes. Researchers and clinicians will find these models indispensable for exploring new avenues of investigation where EED's role could be pivotal.
Our company specializes in providing high-quality biological products optimized for research applications. With a strong commitment to scientific excellence and innovation, we ensure that our EED Gene Knockout Cell Lines are rigorously validated and supported with comprehensive resources to facilitate your research endeavors. Invest in our cell lines to advance your understanding of complex biological systems and contribute to breakthroughs in therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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