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DVL1 Knockout Cell Lines

Gene: DVL1

Official Full Name: dishevelled segment polarity protein 1provided by HGNC

Gene Summary: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00779 DVL1 Knockout cell line(HeLa) Human DVL1 1:3~1:6 Negative Online Inquiry
KO09104 DVL1 Knockout cell line (HCT 116) Human DVL1 1:2~1:4 Negative Online Inquiry
KO09105 DVL1 Knockout cell line (HEK293) Human DVL1 1:3~1:6 Negative Online Inquiry
KO09106 DVL1 Knockout cell line (A549) Human DVL1 1:3~1:4 Negative Online Inquiry

Background

DVL1 Gene Knockout Cell Lines are genetically engineered cellular models that have been specifically designed to lack functional DVL1 (Dishevelled 1), a key component of the Wnt signaling pathway. DVL1 plays a crucial role in various cellular processes, including cell fate determination, proliferation, and differentiation. By utilizing these knockout cell lines, researchers can investigate the exact molecular mechanisms by which DVL1 influences both normal and pathological conditions.

The primary function of DVL1 Gene Knockout Cell Lines is to serve as an effective tool for dissecting Wnt pathway-related signaling events, particularly in the context of development and disease progression. Without the influence of DVL1, researchers can observe phenotypic and genotypic changes that arise from the alteration of canonical and non-canonical Wnt signaling pathways. This provides profound insights into the pathogenesis of diseases such as cancer, neurodegeneration, and developmental disorders.

The scientific importance of these cell lines cannot be overstated. They facilitate cellular studies that lead to a better understanding of the dynamics of Wnt signaling, thus aiding in the identification of potential therapeutic targets. These knockout models are essential for drug discovery and the evaluation of therapeutic agents intended to modulate the Wnt pathway, making them invaluable in both basic research and clinical applications.

DVL1 Gene Knockout Cell Lines stand out in comparison to alternative models, such as wild-type or overexpression cell lines. They provide a clear advantage by minimizing background interference from active DVL1, thus enhancing the clarity of experimental outcomes. This specificity allows for more reliable data in comparative studies and can significantly reduce the complexity of troubleshooting experimental variability.

For researchers and clinicians focused on unraveling the intricacies of cell signaling and its implications on human health, these knockout cell lines are indispensable. They offer a robust platform for studying DVL1's role in oncogenic processes and developmental biology, ultimately aiding the advance of therapeutic strategies.

As a company committed to providing cutting-edge research tools, we pride ourselves on our extensive expertise in genetic engineering and cell line development. Our DVL1 Gene Knockout Cell Lines exemplify our dedication to supporting the scientific community in pioneering discoveries that can transform our understanding of human biology.

Please note that all services are for research use only. Not intended for any clinical use.

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