Gene: DUSP10
Official Full Name: dual specificity phosphatase 10provided by HGNC
Gene Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10870 | DUSP10 Knockout cell line (HeLa) | Human | DUSP10 | 1:3~1:6 | Negative | Online Inquiry |
KO10871 | DUSP10 Knockout cell line (HCT 116) | Human | DUSP10 | 1:2~1:4 | Negative | Online Inquiry |
KO10872 | DUSP10 Knockout cell line (HEK293) | Human | DUSP10 | 1:3~1:6 | Negative | Online Inquiry |
KO10873 | DUSP10 Knockout cell line (A549) | Human | DUSP10 | 1:3~1:4 | Negative | Online Inquiry |
DUSP10 Gene Knockout Cell Lines represent a pivotal tool in the realm of molecular biology, specifically designed to study the regulatory roles of the Dual Specificity Phosphatase 10 (DUSP10) gene in cellular signaling pathways. DUSP10 is known for its role in dephosphorylating mitogen-activated protein kinases (MAPKs), which are critical in transmitting signals for cell proliferation, differentiation, and responses to stress. By utilizing knockout cell lines, researchers can elegantly dissect the functions and pathways influenced by DUSP10, leading to deeper insights into its contributions to various physiological and pathological processes.
These cell lines function by employing CRISPR-Cas9 or similar genome editing technologies to create precise deletions in the DUSP10 gene, thus facilitating the study of its absence and the consequent biological effects. With a lack of DUSP10, the downstream activation of MAPKs can be observed, allowing researchers to understand the implications of disrupted signaling pathways in diseases such as cancer and inflammation.
The scientific importance of DUSP10 Gene Knockout Cell Lines lies in their application across diverse research fields, including oncology, immunology, and cellular biology. In clinical settings, understanding how the knockout of DUSP10 alters cellular behavior can help in identifying novel therapeutic targets, thus progressing the field of personalized medicine.
What sets our DUSP10 Gene Knockout Cell Lines apart from competing products is their verified efficacy and robust stability. We provide extensive documentation and data supporting the functional viability of these lines, ensuring reliability for researchers in obtaining reproducible results. The customization options available allow for tailored experiments that align with specific research objectives, enhancing their versatility.
For researchers and clinicians alike, utilizing DUSP10 Gene Knockout Cell Lines offers a unique opportunity to unravel the complexities of MAPK signaling and develop innovative approaches to treatment strategies. Our dedication to providing high-quality biological products is backed by years of expertise in cell line development and molecular biology, ensuring that our customers receive unparalleled support and expertise in their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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