Gene: DPP9
Official Full Name: dipeptidyl peptidase 9provided by HGNC
Gene Summary: This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23574 | DPP9 Knockout cell line (HeLa) | Human | DPP9 | 1:3~1:6 | Negative | Online Inquiry |
KO23575 | DPP9 Knockout cell line (HCT 116) | Human | DPP9 | 1:2~1:4 | Negative | Online Inquiry |
KO23576 | DPP9 Knockout cell line (HEK293) | Human | DPP9 | 1:3~1:6 | Negative | Online Inquiry |
KO23577 | DPP9 Knockout cell line (A549) | Human | DPP9 | 1:3~1:4 | Negative | Online Inquiry |
DPP9 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack the Dipeptidyl Peptidase 9 (DPP9) gene, a crucial enzyme involved in various biological processes such as immune regulation, metabolic homeostasis, and inflammatory responses. The knockout of DPP9 creates a model that allows researchers to study the role of this enzyme in cellular functions, signaling pathways, and disease states. These cell lines are created using advanced CRISPR-Cas9 technology to ensure precise and efficient editing of the genome, leading to a complete ablation of DPP9 activity.
The key functions of DPP9 involve its regulation of immune responses, particularly its interaction with pro-inflammatory cytokines and its influence on cell signaling. By using DPP9 Gene Knockout Cell Lines, researchers can elucidate the mechanisms underlying diseases characterized by dysregulated immune responses, such as autoimmune disorders and cancer. Additionally, these cell lines facilitate the examination of drug targets and therapeutic strategies, making them invaluable tools in translational research.
The scientific importance of DPP9 Gene Knockout Cell Lines is underscored by their application in both basic and applied research settings. Their ability to define the cellular consequences of DPP9 absence offers insights into potential therapeutic approaches for diseases where DPP9 plays a pivotal role. Compared to alternative models such as conventional cell lines or animal models, these knockout lines provide a more direct approach, allowing for high-throughput screening and functional assays with clear genetic backgrounds.
Researchers and clinicians will find immense value in DPP9 Gene Knockout Cell Lines due to their unique advantage of specificity and reproducibility in experimental outcomes. The well-documented genetic alterations lead to consistent results in experiments, crucial for identifying novel therapeutics and mechanisms of action in drug development.
As a company dedicated to advancing scientific discovery, we pride ourselves on our expertise in producing high-quality, genetically modified cell lines that align with the needs of the research community. Our commitment to rigorous quality control and innovative methodologies ensures that our DPP9 Gene Knockout Cell Lines meet the highest standards, empowering researchers to unlock new possibilities in biomedical research and therapy development.
Please note that all services are for research use only. Not intended for any clinical use.
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