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DNAJC15 Knockout Cell Lines

Gene: DNAJC15

Official Full Name: DnaJ heat shock protein family (Hsp40) member C15provided by HGNC

Gene Summary: Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27150 DNAJC15 Knockout cell line (HeLa) Human DNAJC15 1:3~1:6 Negative Online Inquiry
KO27151 DNAJC15 Knockout cell line (HCT 116) Human DNAJC15 1:2~1:4 Negative Online Inquiry

Background

DNAJC15 Gene Knockout Cell Lines represent a groundbreaking advancement in genetic research, specifically designed to facilitate the study of the DNAJC15 gene and its associated functions. These meticulously engineered cell lines are created through the targeted deletion of the DNAJC15 gene, a crucial participant in the protein folding and stress response processes within cells. By eliminating the gene, researchers can investigate its role in cellular homeostasis, response to stress, and various disease mechanisms, such as neurodegenerative disorders and cancer.

The key function of DNAJC15 is to assist in the proper folding of misfolded proteins, which is essential for maintaining cellular health. In knockout cell lines, scientists can elucidate the consequences of the loss of this chaperone, leading to a better understanding of its imperative role in proteostasis. This mechanistic insight is vital for identifying pathological deviations and exploring potential therapeutic targets.

From a scientific perspective, these knockout cell lines are invaluable in both research and clinical settings. They serve as powerful tools for dissecting the molecular underpinnings of diseases linked to the stress response and protein misfolding, providing a robust model for drug screening and validation. The insights gained from using DNAJC15 knockout cell lines can significantly enhance personalized medicine approaches, particularly in identifying patient-specific therapies.

Compared to alternative models, such as overexpression systems or wild-type cell lines, DNAJC15 knockout cell lines offer a more accurate representation of in vivo conditions, ensuring the results are not confounded by compensatory mechanisms or overactive pathways. This specificity allows for greater predictability in translational applications.

For researchers and clinicians focused on unraveling the complexities of cellular stress and protein misfolding disorders, DNAJC15 Gene Knockout Cell Lines are an essential addition to their toolkit. By harnessing the cutting-edge cell lines produced by our company, which specializes in high-precision genetic tools, users can confidently advance their investigations and contribute to the field with groundbreaking findings. Our commitment to quality and innovation ensures that you receive unparalleled products tailored to meet your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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