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DMC1 Knockout Cell Lines

Gene: DMC1

Official Full Name: DNA meiotic recombinase 1provided by HGNC

Gene Summary: This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31167 DMC1 Knockout cell line (HeLa) Human DMC1 1:3~1:6 Negative Online Inquiry
KO31168 DMC1 Knockout cell line (A549) Human DMC1 1:3~1:4 Negative Online Inquiry

Background

DMC1 Gene Knockout Cell Lines are specifically engineered cellular models that have had the DMC1 gene, a gene crucial for homologous recombination during meiosis, functionally disrupted. This innovative approach provides researchers with valuable tools to study the role of DMC1 in DNA repair mechanisms, meiotic processes, and their implications in fertility and genomic stability.

The key functions of DMC1 involve its participation in the repair of double-strand breaks through homologous recombination, a vital process ensuring genetic diversity during gamete formation. By knocking out DMC1, these cell lines enable scientists to elucidate the biochemical pathways and cellular responses associated with impaired homologous recombination. Researchers can investigate how the absence of DMC1 affects cell proliferation, mutation rates, and overall genomic integrity.

The scientific significance of DMC1 Gene Knockout Cell Lines extends to various fields, including reproductive biology, cancer research, and genetic engineering. This product allows for in-depth studies related to infertility and aneuploidy, contributing to a better understanding of fertility treatments and potential therapeutic strategies. Moreover, these models can serve as platforms for drug testing in oncological research, advancing our knowledge of tumor biology.

Compared to alternative models, DMC1 Gene Knockout Cell Lines offer precise genetic modifications, resulting in consistent and reproducible results. By providing an authentic representation of the DMC1 knockout phenotype, these cell lines reduce variability and increase the reliability of experimental outcomes. Additionally, they are designed for easy integration into standard laboratory workflows, enabling researchers to accelerate their studies.

The value of DMC1 Gene Knockout Cell Lines lies in their ability to provide critical insights into fundamental biological processes, making them essential for both academic and clinical researchers focused on understanding fertility, DNA damage responses, and cancer biology. Overall, our company specializes in delivering high-quality biological research tools, underscoring our commitment to advancing scientific discovery through innovative and reliable products tailored to meet the needs of modern research communities.

Please note that all services are for research use only. Not intended for any clinical use.

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