Home / DMBT1 Knockout Cell Lines

DMBT1 Knockout Cell Lines

Gene: DMBT1

Official Full Name: deleted in malignant brain tumors 1provided by HGNC

Gene Summary: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38218 DMBT1 Knockout cell line (HeLa) Human DMBT1 1:3~1:6 Negative Online Inquiry

Background

DMBT1 Gene Knockout Cell Lines are engineered cellular models that have undergone precise genetic modification to inactivate the DMBT1 gene, which plays a crucial role in various biological processes, including mucosal immunity and tissue development. These knockout cell lines serve as vital tools for understanding the gene's function and its implications in health and disease dynamics.

The primary function of DMBT1 in vitro is to help researchers dissect the contributions of this gene to cellular interactions and signaling pathways. By utilizing these knockout models, scientists can observe the resulting phenotypic changes when DMBT1 is absent, enabling them to explore compensatory mechanisms and alternative pathways activated in its absence. This focus illuminates the gene's role in diseases such as cancer and other chronic conditions, where its expression is often altered.

The scientific importance of DMBT1 Gene Knockout Cell Lines extends to both fundamental and translational research. In preclinical studies, these cell lines provide a platform for drug discovery, enabling the screening of therapeutic compounds aimed at modulating functionality associated with DMBT1. Furthermore, they offer insights into potential therapeutic targets in clinical settings, facilitating the development of innovative strategies for treatment.

One of the unique advantages of using our DMBT1 Gene Knockout Cell Lines lies in their reliability and reproducibility compared to other models that may utilize transient transfection methods or non-specific gene editing approaches. Researchers will find that these stable knockout lines maintain homogeneity and genetic consistency, thus reducing variability in experimental outcomes.

By choosing our DMBT1 Gene Knockout Cell Lines, researchers and clinicians gain access to high-quality models that streamline the exploration of gene functions and their pathological associations. This contributes to a deeper understanding of complex biological systems, ultimately leading to meaningful advancements in health interventions.

At our company, we specialize in providing meticulously validated biological products that empower researchers to conduct cutting-edge work with confidence. Our commitment to excellence in genetic engineering ensures that you will receive products that meet the highest standards in scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.