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DLX2 Knockout Cell Lines

Gene: DLX2

Official Full Name: distal-less homeobox 2provided by HGNC

Gene Summary: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38232 DLX2 Knockout cell line (HeLa) Human DLX2 1:3~1:6 Negative Online Inquiry
KO38233 DLX2 Knockout cell line (HCT 116) Human DLX2 1:2~1:4 Negative Online Inquiry
KO38234 DLX2 Knockout cell line (HEK293) Human DLX2 1:3~1:6 Negative Online Inquiry

Background

DLX2 Gene Knockout Cell Lines are specifically engineered cell lines that have undergone targeted genetic modification to disrupt the expression of the DLX2 gene. This gene plays a crucial role in the development of the nervous system and various aspects of embryogenesis, including the formation of facial structures and cortical development. By creating knockout cell lines, researchers can investigate the functional roles of DLX2 in cellular and molecular processes, significantly enhancing our understanding of its contributions to neurological disorders and development-related pathologies.

The primary mechanism through which these knockout cell lines operate involves the precision editing of the DLX2 gene using advanced CRISPR/Cas9 technology. This ensures a complete and irreversible suppression of DLX2 expression, allowing for comprehensive analyses of phenotypic and genotypic variations in cellular behavior. This research tool is invaluable in elucidating the gene's multifaceted functions, including its influence on neuronal differentiation, proliferation, and interaction with other genetic pathways.

In scientific research and clinical applications, DLX2 Gene Knockout Cell Lines are pivotal for dissecting the molecular underpinnings of conditions such as schizophrenia, autism, and other neurodevelopmental disorders. They also serve as a model system for testing potential therapeutic interventions, paving the way for innovative treatment strategies.

Compared to traditional models, such as wild-type cell lines or less precise genetic modifications, DLX2 Gene Knockout Cell Lines offer enhanced specificity and reliability. Researchers can achieve reproducible results with minimal off-target effects, significantly increasing the validity of their findings. Moreover, these cell lines provide an avenue for high-throughput screening of drug candidates, allowing for faster and more efficient identification of compounds that could modulate DLX2-related pathways.

For researchers and clinicians alike, investing in DLX2 Gene Knockout Cell Lines means accessing a potent tool that can lead to groundbreaking discoveries in neurobiology. Our company specializes in high-quality, customized genetic models and offers extensive support for optimizing their use in diverse research contexts. With a commitment to scientific excellence, we empower your research endeavors with innovative biological products designed to drive forward the frontiers of biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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