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DLGAP4 Knockout Cell Lines

Gene: DLGAP4

Official Full Name: DLG associated protein 4provided by HGNC

Gene Summary: The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30293 DLGAP4 Knockout cell line (HeLa) Human DLGAP4 1:3~1:6 Negative Online Inquiry
KO30294 DLGAP4 Knockout cell line (HCT 116) Human DLGAP4 1:2~1:4 Negative Online Inquiry
KO30295 DLGAP4 Knockout cell line (HEK293) Human DLGAP4 1:3~1:6 Negative Online Inquiry
KO30296 DLGAP4 Knockout cell line (A549) Human DLGAP4 1:3~1:4 Negative Online Inquiry

Background

DLGAP4 Gene Knockout Cell Lines are genetically engineered models specifically designed to facilitate the study of the DLGAP4 gene, which plays a critical role in synaptic development and neuronal function. By employing state-of-the-art CRISPR/Cas9 gene editing technology, these cell lines enable researchers to investigate the biological consequences of DLGAP4 gene deletion, offering unparalleled insight into its regulatory mechanisms involved in processes like synapse formation, signal transduction, and neural plasticity.

The key function of DLGAP4 knockout cell lines lies in their ability to mimic the effects of DLGAP4 deficiency, allowing scientists to observe phenotypic changes at both the cellular and molecular levels. This includes alterations in synaptic structure, dysregulation of neurotransmitter signaling, and aberrant neuronal network activity, all of which can be crucial in understanding neurodevelopmental disorders and neurodegenerative diseases.

Scientifically, DLGAP4 knockout cell lines hold significant importance in research settings, particularly in neuroscience, pharmacology, and genetic studies. They can serve as valuable tools for drug discovery and development, enabling investigators to assess the therapeutic potential of compounds targeting synaptic dysfunctions. Additionally, they can be utilized in basic research to elucidate the roles of the DLGAP4 gene in complex biological processes.

Compared to traditional models, DLGAP4 knockout cell lines offer the unique selling points of high specificity and reproducibility. They minimize background noise by eliminating the variable expression of the target gene, which is often seen in other experimental setups. Importantly, these cell lines also provide a standardized platform for high-throughput screening, thereby accelerating the pace of discovery.

For researchers and clinicians working towards advancing our understanding of synaptic biology and related disorders, DLGAP4 Gene Knockout Cell Lines represent a valuable resource that enhances experimental outcomes and drives innovation. With our company’s extensive expertise in gene editing technologies and cell line development, we are committed to providing high-quality biological products that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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