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DIS3L Knockout Cell Lines

Gene: DIS3L

Official Full Name: DIS3 like exosome 3'-5' exoribonucleaseprovided by HGNC

Gene Summary: The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30590 DIS3L Knockout cell line (HeLa) Human DIS3L 1:3~1:6 Negative Online Inquiry
KO30591 DIS3L Knockout cell line (HCT 116) Human DIS3L 1:2~1:4 Negative Online Inquiry
KO30592 DIS3L Knockout cell line (HEK293) Human DIS3L 1:3~1:6 Negative Online Inquiry
KO30593 DIS3L Knockout cell line (A549) Human DIS3L 1:3~1:4 Negative Online Inquiry

Background

DIS3L Gene Knockout Cell Lines are cutting-edge biological tools designed for the study of gene function, regulation, and therapeutic intervention. These cell lines have been genetically engineered to exhibit a complete knockout of the DIS3L gene, which plays a pivotal role in RNA metabolism, cellular growth, and gene expression regulation. By eliminating the activity of the DIS3L gene, researchers can investigate its contributions to cellular processes, particularly in the context of tumor biology and other diseases stemming from dysregulated RNA handling.

The primary function of DIS3L is associated with the exoribonuclease activity that contributes to RNA decay pathways and post-transcriptional control. Through the knockout of this gene in these cell lines, scientists can elucidate the downstream effects on RNA stability and turnover within the cell, offering insights into mechanisms that can lead to various pathologies, including cancer. This unique feature makes the DIS3L Gene Knockout Cell Lines indispensable for researchers focused on RNA biology and gene expression studies.

The scientific importance of these cell lines is profound as they provide a robust platform for drug discovery and development, particularly for therapies targeting RNA metabolism. Their applications extend to studies related to cancer research, neurological disorders, and metabolic diseases, where altered RNA processing plays a significant role.

What sets DIS3L Gene Knockout Cell Lines apart from traditional models is their specificity and reliability. Unlike other gene manipulation techniques that may have off-target effects, our knockout lines provide a precise and consistent genetic background, ensuring experimental reproducibility. Additionally, they come with thorough documentation and characterization, allowing researchers to immediately implement them into their work without extensive validation processes.

For researchers and clinicians, the value of DIS3L Gene Knockout Cell Lines lies in their innovative approach to tackling complex biological questions while enabling rigorous scientific investigation. By utilizing these cell lines, users can accelerate their research endeavors, ultimately leading to novel therapeutic strategies that could significantly impact patient care.

At our company, we pride ourselves on being at the forefront of genetic engineering and cell line development, ensuring our products not only meet rigorous scientific standards but also empower the global research community in their quest for discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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