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DIAPH3 Knockout Cell Lines

Gene: DIAPH3

Official Full Name: diaphanous related formin 3provided by HGNC

Gene Summary: This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03165 DIAPH3 Knockout cell line (HeLa) Human DIAPH3 1:3~1:6 Negative Online Inquiry
KO03166 DIAPH3 Knockout cell line (HCT 116) Human DIAPH3 1:2~1:4 Negative Online Inquiry
KO03167 DIAPH3 Knockout cell line (HEK293) Human DIAPH3 1:3~1:6 Negative Online Inquiry
KO03168 DIAPH3 Knockout cell line (A549) Human DIAPH3 1:3~1:4 Negative Online Inquiry

Background

DIAPH3 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the DIAPH3 gene, a pivotal regulator in actin dynamics and cellular mechanics. These knockout cell lines enable researchers to investigate the effects of DIAPH3 depletion on a cellular level, facilitating an in-depth understanding of its role in cytoskeletal organization, cell motility, and overall cellular function.

The core mechanism through which DIAPH3 influences these processes involves the regulation of filamentous actin, a crucial component of the cytoskeleton. By modulating actin polymerization and stability, DIAPH3 plays an essential role in various cellular activities such as migration, division, and shape maintenance. By employing our DIAPH3 Gene Knockout Cell Lines, researchers can explore how the absence of this gene impacts cellular behaviors, elucidating its contribution to various pathophysiological conditions, including cancer metastasis and developmental disorders.

The scientific importance of these cell lines extends into both research and clinical settings. They serve as invaluable tools for studying the molecular mechanisms underlying diseases where cytoskeletal integrity is compromised. Their applications range from drug discovery and vaccine development to gene therapy approaches, as understanding the mechanisms at play in DIAPH3 knockout conditions can lead to innovative therapeutic interventions.

Compared to alternative models, our DIAPH3 Gene Knockout Cell Lines offer distinctive advantages, including validated knockout efficiency and robustness in various experimental conditions. They are rigorously characterized to ensure reproducibility and reliability in experimental results, which is critical for high-stakes research.

For researchers and clinicians seeking to push the boundaries of understanding in cellular mechanics and related diseases, the DIAPH3 Gene Knockout Cell Lines provide a reliable and powerful resource. With a commitment to quality and innovation, our company delivers expert-crafted biological products designed to accelerate scientific discovery and enhance research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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