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DHX32 Knockout Cell Lines

Gene: DHX32

Official Full Name: DEAH-box helicase 32 (putative)provided by HGNC

Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18291 DHX32 Knockout cell line (HeLa) Human DHX32 1:3~1:6 Negative Online Inquiry
KO18292 DHX32 Knockout cell line (HCT 116) Human DHX32 1:2~1:4 Negative Online Inquiry
KO18293 DHX32 Knockout cell line (HEK293) Human DHX32 1:3~1:6 Negative Online Inquiry
KO18294 DHX32 Knockout cell line (A549) Human DHX32 1:3~1:4 Negative Online Inquiry

Background

DHX32 Gene Knockout Cell Lines are precisely engineered cellular models where the DHX32 gene has been effectively disrupted, facilitating the study of its biological functions and implications in various disease processes. These cell lines serve as vital tools in molecular biology and genetics, enabling researchers to investigate the role of DHX32 in cellular processes such as RNA metabolism, gene expression regulation, and response to stress.

The operational mechanism of DHX32 Gene Knockout Cell Lines involves the targeted editing of the DHX32 locus through advanced techniques such as CRISPR-Cas9 or homologous recombination. By creating specific mutations that render the DHX32 protein non-functional, researchers can observe the downstream effects on various biochemical pathways. This cellular model is invaluable, particularly in elucidating the role of DHX32 in cancer biology, chronic diseases, and developmental processes.

Scientifically, the importance of DHX32 knockout models is multifaceted. In research settings, they allow for the assessment of gene function and interaction with other molecular partners, fostering insights into essential biological pathways. Clinically, understanding DHX32's functions can lead to potential therapeutic targets for diseases linked to its dysfunction, thereby providing a pathway for innovative treatments.

Compared to alternative models, DHX32 Gene Knockout Cell Lines offer a high degree of specificity and reproducibility. While traditional methods may utilize siRNA or chemical inhibitors, these approaches often introduce off-target effects or transient changes. The gene knockout provides a stable, long-term model that maintains a consistent phenotype, which is critical for rigorous scientific inquiry.

For researchers and clinicians focused on genetics, cellular biology, or therapeutic development, the DHX32 Gene Knockout Cell Lines represent a potent resource that can enhance experimental outcomes and provide deeper insights into gene function. Our company possesses a robust background in genetic engineering and cellular model development, ensuring that our products are of the highest caliber and tailored to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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