Gene: DENND6A
Official Full Name: DENN domain containing 6Aprovided by HGNC
Gene Summary: Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell-cell adhesion mediated by cadherin. Located in recycling endosome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37165 | DENND6A Knockout cell line (HeLa) | Human | DENND6A | 1:3~1:6 | Negative | Online Inquiry |
KO37166 | DENND6A Knockout cell line (HCT 116) | Human | DENND6A | 1:2~1:4 | Negative | Online Inquiry |
KO37167 | DENND6A Knockout cell line (HEK293) | Human | DENND6A | 1:3~1:6 | Negative | Online Inquiry |
KO37168 | DENND6A Knockout cell line (A549) | Human | DENND6A | 1:3~1:4 | Negative | Online Inquiry |
DENND6A Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate the study of the DENND6A gene's biological functions and its implications in various physiological processes. These cell lines utilize CRISPR/Cas9 gene editing technology to create robust, reproducible knockout models that lack functional DENND6A expression, enabling researchers to investigate the downstream effects of DENND6A absence.
The primary mechanism of action revolves around the targeted disruption of the DENND6A gene, which encodes a protein involved in intracellular trafficking and signaling pathways. By watching how these knockout cell lines behave in both normal and stress conditions, researchers can elucidate the role DENND6A plays in cellular processes such as autophagy, endocytosis, and immune responses. This makes them invaluable for both basic research and translational studies focusing on diseases where DENND6A may be implicated, such as neurodegeneration and cancer.
The scientific importance of DENND6A Gene Knockout Cell Lines lies not only in their utility for basic research but also in their applications in drug discovery and the development of novel therapeutic strategies. By understanding how the loss of DENND6A affects cellular responses, researchers can target specific networks for pharmaceutical interventions, enhancing drug efficacy and patient outcomes.
What sets our DENND6A Gene Knockout Cell Lines apart from competitors is their superior validation process, which ensures reliable and reproducible results. Our cell lines are confirmed through rigorous genotyping and functional assays, providing users with confidence in their experimental outcomes. Furthermore, our intuitive user guide and dedicated customer support make it easier for researchers and clinicians to seamlessly integrate these tools into their work.
For researchers, clinicians, and pharmaceutical companies, utilizing DENND6A Gene Knockout Cell Lines unlocks a treasure trove of insights into gene function and disease mechanisms. Our company’s commitment to providing high-quality, scientifically accurate biological products is backed by years of expertise, ensuring that our clients receive only the best tools for their research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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