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DENND1A Knockout Cell Lines

Gene: DENND1A

Official Full Name: DENN domain containing 1Aprovided by HGNC

Gene Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18340 DENND1A Knockout cell line (HeLa) Human DENND1A 1:3~1:6 Negative Online Inquiry
KO18341 DENND1A Knockout cell line (HCT 116) Human DENND1A 1:2~1:4 Negative Online Inquiry
KO18342 DENND1A Knockout cell line (HEK293) Human DENND1A 1:3~1:6 Negative Online Inquiry
KO18343 DENND1A Knockout cell line (A549) Human DENND1A 1:3~1:4 Negative Online Inquiry

Background

DENND1A Gene Knockout Cell Lines are specialized cellular models engineered to lack the DENND1A gene, which encodes a protein involved in various cellular processes, including endosomal trafficking and actin cytoskeleton dynamics. These knockout cell lines serve as vital tools for investigating gene function and examining the physiological consequences of DENND1A deficiency in both in vitro and in vivo settings.

The primary function of DENND1A involves facilitating the activation of specific small GTPases, which are critical for regulating intracellular signaling pathways. By disrupting the expression of this gene, researchers can elucidate its role in cellular mechanisms such as receptor endocytosis, cytokine signaling, and migration. This opens pathways for assessing the impact of DENND1A on cancer biology, neurodegenerative diseases, and immune responses.

In research and clinical applications, DENND1A Gene Knockout Cell Lines hold significant potential for functional studies that aim to dissect the gene's contribution to disease models. This tool is especially valuable for gene-editing initiatives and drug discovery programs, where understanding the basic biology and pathology related to DENND1A can inform therapeutic strategies. Moreover, the availability of knockout models accelerates validation of findings from genome-wide association studies that implicate this gene in various diseases.

What sets our DENND1A Gene Knockout Cell Lines apart from competing products is their precise validation through CRISPR technology, ensuring complete and reproducible deletion of the target gene. These cell lines are rigorously characterized to guarantee authentic performance, allowing researchers to rely on them across various experimental conditions.

For researchers and clinicians alike, these cell lines are invaluable for exploring specialized gene functions and developing therapeutic interventions. By offering a robust platform for innovative research, our company stands at the forefront of genetic tools, leveraging deep expertise in gene editing and cellular biology to deliver cutting-edge products that empower scientific discovery and application.

Please note that all services are for research use only. Not intended for any clinical use.

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