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DDX5 Knockout Cell Lines

Gene: DDX5

Official Full Name: DEAD-box helicase 5provided by HGNC

Gene Summary: This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05437 DDX5 Knockout cell line (HeLa) Human DDX5 1:3~1:6 Negative Online Inquiry
KO05438 DDX5 Knockout cell line (HCT 116) Human DDX5 1:2~1:4 Negative Online Inquiry
KO05439 DDX5 Knockout cell line (HEK293) Human DDX5 1:3~1:6 Negative Online Inquiry

Background

DDX5 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disrupt the DDX5 gene, which encodes a RNA helicase involved in various aspects of RNA metabolism, including splicing, translation, and degradation. By utilizing CRISPR-Cas9 technology, these cell lines allow researchers to investigate the biological functions and regulatory pathways associated with DDX5 more comprehensively. The knockout of this gene serves as a powerful tool for understanding its role in cellular mechanisms, particularly in oncogenesis, developmental biology, and responses to stressors.

The DDX5 Gene Knockout Cell Lines exhibit distinct phenotypic and functional characteristics compared to wild-type counterparts. By assessing these differences, researchers can elucidate the contributions DDX5 makes to cellular homeostasis, gene expression regulation, and the interaction of RNA with proteins. The ability to selectively eliminate DDX5 offers insightful perspectives on how its dysregulation may lead to disease states, including various cancers and genetic disorders.

In the realms of research and clinical applications, these knockout cell lines can facilitate high-throughput screening, drug development, and targeted therapeutic strategies. They provide a reliable assay platform for evaluating the impact of potential pharmaceuticals on cellular pathways influenced by DDX5, ultimately aiding in the identification of novel therapeutic targets for disease management.

One of the key advantages of DDX5 Gene Knockout Cell Lines is their specificity and reproducibility, enabling experimental designs that yield high-quality, interpretable results. Unlike traditional RNA interference approaches, CRISPR-mediated knockout can ensure complete and permanent disruption of the gene, leading to a more profound insight into its functions.

The DDX5 Gene Knockout Cell Lines are indispensable resources for researchers and clinicians seeking to deepen their understanding of RNA metabolic processes and their implications for human health. Our commitment to providing high-quality, genetically modified cell lines, backed by extensive expertise in molecular biology and gene editing technologies, empowers scientists to push the boundaries of discovery in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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