Gene: DDX3Y
Official Full Name: DEAD-box helicase 3 Y-linkedprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33972 | DDX3Y Knockout cell line (HCT 116) | Human | DDX3Y | 1:2~1:4 | Negative | Online Inquiry |
KO33973 | DDX3Y Knockout cell line (A549) | Human | DDX3Y | 1:3~1:4 | Negative | Online Inquiry |
DDX3Y Gene Knockout Cell Lines are a specialized tool in molecular biology designed to facilitate the study of gene functions associated with the DDX3Y gene, which encodes a member of the DEAD-box RNA helicase family. These knockout cell lines are engineered to have the DDX3Y gene selectively disrupted, allowing researchers to investigate the biological roles and mechanisms of this gene in various cellular processes and disease models.
The primary function of DDX3Y involves its participation in RNA metabolism, including mRNA translation, splicing, and degradation. By utilizing knockout cell lines, researchers can elucidate the pathways impacted by the absence of DDX3Y, enhance their understanding of gene regulation in physiological and pathological contexts, and identify potential therapeutic targets for diseases such as tumors, infections, and genetic disorders. The detailed analysis of these mechanisms in knockout models is crucial for advancing both fundamental biology and translational research.
The scientific importance of DDX3Y Gene Knockout Cell Lines extends into various applications, including drug discovery, cancer research, and studies of male fertility and genetic disorders linked to Y chromosome deletions. Compared to traditional cell models, these knockout lines provide a clean genetic background, ensuring that observed phenotypes are accurately attributed to the targeted gene modification, thus offering clarity and reliability in experimental outcomes.
What sets our DDX3Y Gene Knockout Cell Lines apart from alternatives available on the market is the precision of our genomic editing technique, which ensures high efficiency in gene disruption with minimal off-target effects. Additionally, our cell lines are validated for consistent performance across multiple research platforms, allowing for seamless integration into various experimental protocols. This reliability reinforces the rigorous scientific demands of modern research and development.
For researchers and clinicians involved in genetics, cancer biology, or reproductive health, DDX3Y Gene Knockout Cell Lines offer a valuable asset, enabling them to achieve high-quality, reproducible results that enhance our understanding of gene function and open avenues for innovative therapeutic strategies. Our company is committed to providing advanced biological products backed by a team of experts with extensive experience in gene editing and cellular biology, ensuring that our customers have access to the highest quality tools that meet their research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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