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DDX21 Knockout Cell Lines

Gene: DDX21

Official Full Name: DExD-box helicase 21provided by HGNC

Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00309 DDX21 gRNA11-gRNA12 KO plasmid DDX21 $850
GP00393 DDX21 gRNA1-gRNA2 KO plasmid DDX21 $850
KO00682 DDX21 Knockout cell line(HEK293) Human DDX21 1:3~1:6 Negative Online Inquiry

Background

DDX21 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the expression of the DDX21 gene, which encodes a RNA helicase crucial for various aspects of RNA metabolism, including transcriptional regulation and ribosome biogenesis. The creation of these knockout lines facilitates the study of DDX21's function in cellular processes, providing researchers with valuable insights into the broader implications of RNA processing and gene expression regulation.

The key feature of DDX21 Gene Knockout Cell Lines is the precise removal of DDX21’s genetic sequence through CRISPR-Cas9 technology. This innovative method allows for highly accurate targeting and disruption of the gene, resulting in a clearer understanding of the gene's role in cellular mechanisms. Researchers can assess how the absence of DDX21 impacts RNA synthesis, splicing, and overall cell function, making these cell lines essential tools in the field of molecular biology.

Scientifically, DDX21 knockout cell lines contribute significantly to studies in oncology, virology, and genetic disorders, as alterations in RNA metabolism are linked to various diseases. Their application in both research and clinical settings enables a thorough investigation of the gene's influence on disease progression, treatment response, and potential therapeutic targets.

In comparison to other genetic manipulation alternatives, the DDX21 Gene Knockout Cell Lines stand out for their reliability and ease of use. They provide a robust platform for consistent experimental results, which is critical for obtaining reproducible outcomes in research. Additionally, their specific focus on DDX21 allows for a deeper exploration of gene interactions within complex cellular networks, offering researchers a distinct advantage over more generalized cell models.

For researchers and clinicians seeking to advance their understanding of gene function in health and disease, DDX21 Gene Knockout Cell Lines represent a powerful resource. The elimination of the DDX21 gene empowers investigations into RNA biology and related therapeutic approaches, making these cell lines invaluable assets in the quest for scientific knowledge and innovation.

Our company prides itself on its commitment to harnessing cutting-edge genetic engineering technologies to provide high-quality biological products that enhance research capabilities and contribute to scientific advancements in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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