Gene: DDC
Official Full Name: dopa decarboxylaseprovided by HGNC
Gene Summary: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38273 | DDC Knockout cell line (A549) | Human | DDC | 1:3~1:4 | Negative | Online Inquiry |
DDC Gene Knockout Cell Lines are genetically modified cellular models created through the targeted disruption of the DDC gene, which encodes for the enzyme Dopa Decarboxylase. This product offers a powerful tool in molecular biology research for studying neurodevelopmental and neuropsychiatric disorders, as the DDC enzyme plays a crucial role in the synthesis of neurotransmitters such as dopamine and serotonin. By employing CRISPR-Cas9 technology, these cell lines exhibit a stable knockout of the DDC gene, allowing researchers to investigate the corresponding phenotypic changes and cellular mechanisms underlying dopamine-related pathways.
The primary function of DDC Gene Knockout Cell Lines is to serve as an experimental platform for elucidating the physiological and biochemical roles of the DDC enzyme. By comparing the knockout lines to wild-type controls, scientists can assess alterations in neurotransmitter levels, receptor activity, and pathway interactions, thus enhancing the understanding of conditions such as Parkinson’s disease and depression. In clinical settings, these cell lines can be utilized for drug screening and the development of therapeutic strategies that target dopamine dysregulation.
What sets DDC Gene Knockout Cell Lines apart from other genetic models is their precision and reliability in simulating human disease states. Alternative models, such as animal models or non-targeted knockdowns, can show variability in results and may not fully recapitulate human pathology. In contrast, these knockout cell lines provide consistent and reproducible data, making them invaluable for academic research and pharmaceutical development.
Researchers and clinicians alike will find these cell lines essential for advancing knowledge in neuropharmacology and genetics, offering a cost-effective solution to complex biological questions. Our commitment to high-quality genetic tools ensures that DDC Gene Knockout Cell Lines are produced under stringent standards, guaranteeing their suitability for both exploratory and translational research purposes. Our expertise in gene editing and cellular biology positions us as a leader in providing cutting-edge biological products that drive innovation in scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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