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DCXR Knockout Cell Lines

Gene: DCXR

Official Full Name: dicarbonyl and L-xylulose reductaseprovided by HGNC

Gene Summary: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22894 DCXR Knockout cell line (HeLa) Human DCXR 1:3~1:6 Negative Online Inquiry
KO22895 DCXR Knockout cell line (HCT 116) Human DCXR 1:2~1:4 Negative Online Inquiry
KO22896 DCXR Knockout cell line (HEK293) Human DCXR 1:3~1:6 Negative Online Inquiry
KO22897 DCXR Knockout cell line (A549) Human DCXR 1:3~1:4 Negative Online Inquiry

Background

DCXR Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the DCXR gene, which encodes the enzyme Dicarbonyl/L-xylulose reductase. This enzyme plays a crucial role in the metabolism of carbohydrates and the detoxification of harmful dicarbonyl compounds that can arise during various physiological processes. The creation of DCXR knockout cell lines allows researchers to delve into the enzyme's specific functions, assess metabolic pathways, and study the implications of its absence in cellular physiology.

The key functions of these knockout cell lines involve advancing our understanding of metabolic dysregulation and the cellular mechanisms underlying diseases such as diabetes. By providing a system devoid of DCXR expression, these cell lines facilitate the examination of compensatory pathways, metabolic stress responses, and the potential accumulation of toxic metabolites. Researchers can employ these models to investigate the roles of DCXR in cellular health, making them invaluable for studies aimed at elucidating disease mechanisms and developing therapeutic strategies.

In both research and clinical contexts, DCXR gene knockout cell lines hold significant scientific importance, particularly in fields focusing on metabolic diseases, pharmacology, and toxicology. Their unique ability to mimic conditions of DCXR deficiency enables thorough investigation of how such a deficiency affects cellular function, responses to therapeutics, and overall metabolism.

Compared to traditional cell lines, DCXR knockout cell lines offer distinct advantages by providing a more precise model for studying the specific effects of DCXR gene loss. Traditional methodologies such as chemical inhibition can be nonspecific, whereas these genetically modified cell lines allow for a cleaner exploration of genetic impacts, resulting in more reliable data.

For researchers and clinicians, the value of DCXR gene knockout cell lines lies in their capacity to advance the understanding of metabolic pathways, ultimately influencing the development of targeted therapies and enhancing patient care strategies. Our company is at the forefront of delivering high-quality, rigorously validated biological products, backed by years of experience in the field, ensuring that our offerings support your research endeavors with reliability and precision.

Please note that all services are for research use only. Not intended for any clinical use.

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