Home / DCLRE1A Knockout Cell Lines

DCLRE1A Knockout Cell Lines

Gene: DCLRE1A

Official Full Name: DNA cross-link repair 1Aprovided by HGNC

Gene Summary: This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32481 DCLRE1A Knockout cell line (HeLa) Human DCLRE1A 1:3~1:6 Negative Online Inquiry
KO32482 DCLRE1A Knockout cell line (HCT 116) Human DCLRE1A 1:2~1:4 Negative Online Inquiry
KO32483 DCLRE1A Knockout cell line (HEK293) Human DCLRE1A 1:3~1:6 Negative Online Inquiry
KO32484 DCLRE1A Knockout cell line (A549) Human DCLRE1A 1:3~1:4 Negative Online Inquiry

Background

DCLRE1A Gene Knockout Cell Lines are engineered cellular models designed for the specific study of the DCLRE1A gene, known to be involved in DNA repair mechanisms, particularly in the context of the repair of DNA double-strand breaks. These cell lines have been meticulously constructed to exhibit a complete knockout of the DCLRE1A gene, facilitating a deeper understanding of its biological role and the molecular pathways associated with DNA damage response and repair processes.

The primary mechanism of action for these knockout cell lines lies in their ability to allow researchers to observe the effects of the absence of DCLRE1A on cellular function, particularly its impacts on genomic stability, cell cycle regulation, and apoptosis. By utilizing these cell lines in experimental setups, scientists can investigate the underlying genetic causes of diseases like cancer, where DNA repair pathways are often dysregulated.

The scientific importance of DCLRE1A Gene Knockout Cell Lines spans both fundamental research and clinical applications, including advancing cancer biology studies and exploring therapeutic strategies for enhancing DNA repair mechanisms in patients suffering from genetic disorders. By studying these knockout lines, researchers can develop insights that may lead to innovative treatment options or the identification of biomarkers for disease susceptibility.

What sets our DCLRE1A Gene Knockout Cell Lines apart from other cellular models is their precise genetic modification achieved through advanced CRISPR/Cas9 technology, ensuring a reliable and reproducible experimental design. Additionally, our cell lines come with robust lineage authenticity and extensive characterization, giving researchers confidence in their experimental outcomes.

Investing in DCLRE1A Gene Knockout Cell Lines equips researchers and clinicians with cutting-edge tools essential for advancing their studies in genetic repair mechanisms and contributes to the broader understanding of cellular responses to DNA damage. Our commitment to quality and expertise in developing innovative biological products ensures that you receive a premier research solution that meets the stringent demands of contemporary scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.